TY - JOUR
T1 - The interactive effects of environmental enrichment and extinction interventions in attenuating cue-elicited cocaine-seeking behavior in rats
AU - Thiel, Kenneth J.
AU - Engelhardt, Ben
AU - Hood, Lauren E.
AU - Peartree, Natalie A.
AU - Neisewander, Janet
N1 - Funding Information:
This work was supported by grants R01DA11064 , R21DA023123 , and F31DA023746 from the National Institute on Drug Abuse (NIDA) . The content is solely the responsibility of the authors and does not necessarily represent the official view of NIDA or the National Institutes of Health. The authors wish to thank Mike Painter, Nathan Pentkowski, Lara Pockros, and Ryan Bastle for their expert technical assistance with surgery, Suzanne Weber for assistance with setting up environmental enrichment conditions, and Dr. Timothy Cheung for the helpful comments on the manuscript.
PY - 2011/1
Y1 - 2011/1
N2 - Cues associated with cocaine can elicit craving and relapse. Attempts have been made to employ extinction therapy, which is aimed at attenuating the incentive motivational effects of cocaine cues, as a treatment for cocaine addiction; however, this approach has been largely unsuccessful perhaps due to the inability to extinguish all cues associated with cocaine use while in a clinic. Recently, environmental enrichment (EE) during abstinence has been proposed as a strategy to attenuate cue-elicited cocaine craving. The present study used an animal model to examine whether the utility of extinction toward attenuating cue-elicited cocaine-seeking behavior could be enhanced by also providing EE. All rats were trained to self-administer cocaine while housed in isolated conditions and then subsequently underwent 17 days of forced abstinence, during which they were either housed in pairs or under EE and they either received daily 1-h extinction sessions or similar handling without exposure to the self-administration environment. Following this intervention period, all rats were tested for cue-elicited cocaine-seeking behavior. To examine whether effects of these interventions persist, all rats were subsequently single-housed for an additional 7-day forced abstinence period, followed by a second test for cue-elicited cocaine-seeking behavior. We found that although daily extinction training and EE each attenuated subsequent cue-elicited cocaine-seeking behavior, the combined treatment of extinction training + EE completely prevented it. However, once these interventions were discontinued, their protective effects diminished. These findings suggest that combining behavioral therapy approaches may improve outcomes; however, future work is needed to improve the longevity of these strategies beyond their implementation.
AB - Cues associated with cocaine can elicit craving and relapse. Attempts have been made to employ extinction therapy, which is aimed at attenuating the incentive motivational effects of cocaine cues, as a treatment for cocaine addiction; however, this approach has been largely unsuccessful perhaps due to the inability to extinguish all cues associated with cocaine use while in a clinic. Recently, environmental enrichment (EE) during abstinence has been proposed as a strategy to attenuate cue-elicited cocaine craving. The present study used an animal model to examine whether the utility of extinction toward attenuating cue-elicited cocaine-seeking behavior could be enhanced by also providing EE. All rats were trained to self-administer cocaine while housed in isolated conditions and then subsequently underwent 17 days of forced abstinence, during which they were either housed in pairs or under EE and they either received daily 1-h extinction sessions or similar handling without exposure to the self-administration environment. Following this intervention period, all rats were tested for cue-elicited cocaine-seeking behavior. To examine whether effects of these interventions persist, all rats were subsequently single-housed for an additional 7-day forced abstinence period, followed by a second test for cue-elicited cocaine-seeking behavior. We found that although daily extinction training and EE each attenuated subsequent cue-elicited cocaine-seeking behavior, the combined treatment of extinction training + EE completely prevented it. However, once these interventions were discontinued, their protective effects diminished. These findings suggest that combining behavioral therapy approaches may improve outcomes; however, future work is needed to improve the longevity of these strategies beyond their implementation.
KW - Cocaine
KW - Cue reinstatement
KW - Environmental enrichment
KW - Extinction
KW - Incentive motivation
KW - Social housing
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U2 - 10.1016/j.pbb.2010.09.014
DO - 10.1016/j.pbb.2010.09.014
M3 - Article
C2 - 20869391
AN - SCOPUS:78650173608
SN - 0091-3057
VL - 97
SP - 595
EP - 602
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 3
ER -