Abstract
A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.
Original language | English (US) |
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Pages (from-to) | 705-711 |
Number of pages | 7 |
Journal | British Journal of Cancer |
Volume | 71 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1995 |
ASJC Scopus subject areas
- Oncology
- Cancer Research