The interaction with tubulin of a series of stilbenes based on combretastatin A-4

J. A. Woods, J. A. Hadfield, George Pettit, B. W. Fox, A. T. McGown

Research output: Contribution to journalArticlepeer-review

168 Scopus citations

Abstract

A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.

Original languageEnglish (US)
Pages (from-to)705-711
Number of pages7
JournalBritish Journal of Cancer
Volume71
Issue number4
DOIs
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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