We studied the interaction of normal human serum immunoglobulins with outer‐membrane bleb antigens of Neisseria gonorrhoeae. Gonococcal 68000 Dalton and Lip (H.8 antigen) outer‐membrane proteins were recognized by normal human serum immunoglobulins in blebs from serum‐resistant strains, but not in blebs from serum‐susceptible strains. The addition of blebs from a serum‐resistant strain to bactericidal assays resulted in significantly greater inhibition of serum killing than the addition of blebs from a serum‐susceptible strain. Our results indicate that blebs from two serum‐resistant gonococcal strains have an enhanced ability to bind and remove cell‐targeted bactericidal factors, and that outer‐membrane bleb‐bing may contribute to serum resistance.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Mar 1992|
ASJC Scopus subject areas
- Molecular Biology