The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas

Jason M. Bodily, David J. Hoopes, Beverly L. Roeder, Sharon G. Gilbert, George Pettit, Cherry L. Herald, Darin N. Rollins, Richard A. Robison

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 μg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalCancer Letters
Volume136
Issue number1
DOIs
StatePublished - Feb 8 1999

Keywords

  • Bryostatin 1
  • Cancer therapeutics
  • Cervical cancer
  • PKC
  • Papillomavirus

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Bodily, J. M., Hoopes, D. J., Roeder, B. L., Gilbert, S. G., Pettit, G., Herald, C. L., Rollins, D. N., & Robison, R. A. (1999). The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas. Cancer Letters, 136(1), 67-74. https://doi.org/10.1016/S0304-3835(98)00310-3