The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas

Jason M. Bodily; David J. Hoopes; Beverly L. Roeder; Sharon G. Gilbert; George Pettit; Cherry L. Herald; Darin N. Rollins; Richard A. Robison

doi:10.1016/S0304-3835(98)00310-3

The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas

Jason M. Bodily, David J. Hoopes, Beverly L. Roeder, Sharon G. Gilbert, George Pettit, Cherry L. Herald, Darin N. Rollins, Richard A. Robison

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 μg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	67-74
Number of pages	8
Journal	Cancer Letters
Volume	136
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(98)00310-3
State	Published - Feb 8 1999

Keywords

Bryostatin 1
Cancer therapeutics
Cervical cancer
PKC
Papillomavirus

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/S0304-3835(98)00310-3

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title = "The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas",

abstract = "Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 μg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

keywords = "Bryostatin 1, Cancer therapeutics, Cervical cancer, PKC, Papillomavirus",

author = "Bodily, {Jason M.} and Hoopes, {David J.} and Roeder, {Beverly L.} and Gilbert, {Sharon G.} and George Pettit and Herald, {Cherry L.} and Rollins, {Darin N.} and Robison, {Richard A.}",

note = "Funding Information: We would like to thank Steve Moss, Steve Baldwin, David Eldredge, Brett Cherry, and Mata Cain for their assistance in the lab. This study was funded in part by grants from The Brigham Young University Professional Development Committee and the BYU Cancer Research Center.",

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AU - Herald, Cherry L.

AU - Rollins, Darin N.

AU - Robison, Richard A.

N1 - Funding Information: We would like to thank Steve Moss, Steve Baldwin, David Eldredge, Brett Cherry, and Mata Cain for their assistance in the lab. This study was funded in part by grants from The Brigham Young University Professional Development Committee and the BYU Cancer Research Center.

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N2 - Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 μg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - Bryostatin 1 is a protein kinase C modulator that shows antineoplastic activity in a variety of tumor systems. This study examined the effects of bryostatin 1 administration on papilloma growth in rabbits. Investigations of optimal route, dose, and schedule were performed. Several groups of rabbits were inoculated with cottontail rabbit papillomavirus (CRPV) DNA. Bryostatin 1 was administered i.v., both daily and weekly, and intralesionally both weekly and bi-weekly. Intralesionally dosed papillomas were examined histologically for immune cell infiltration. In weekly and daily i.v. trials, 2.5 and 1.0 μg/kg, respectively, showed the greatest overall reduction in tumor size. Bryostatin 1 administered intralesionally also slowed papilloma growth. Treated lesions had significantly higher numbers of heterophils and eosinophils. Copyright (C) 1999 Elsevier Science Ireland Ltd.

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The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas

Abstract

Keywords

ASJC Scopus subject areas

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