TY - JOUR
T1 - The influence of personality factors on disease progression and healthrelated quality of life in people with ALS
AU - Krampe, Henning
AU - Bartels, Claudia
AU - Victorson, David
AU - Enders, Craig E.
AU - Beaumont, Jennifer
AU - Cella, David
AU - Ehrenreich, Hannelore
N1 - Funding Information:
The authors wish to thank Jeannine Dietrich and Nina Mertens for their help in data collection. We would also like to thank the patients and their relatives who devoted financial aid for the clinical trial. This study was supported by a fellowship within the postdoctoral program of the German Academic Exchange Service (DAAD), and by the US National Institute of Neurological Disorders and Stroke (NINDS).
PY - 2008
Y1 - 2008
N2 - We aimed to perform a prospective long-term follow-up of health-related quality of life (QOL) in ALS and to investigate the relationship of personality factors with changes in QOL and disease progression.Data on QOL were collected prospectively for 12 months from 31 ALS patients. Personality factors were studied using the NEO-FFI (NEO Five Factor Inventory). Monthly self-ratings of global QOL, and seven health-related QOL functions, as well as ALSFRS (ALS Functional Rating Scale) scores were analyzed using a linear mixed model approach. QOL and ALSFRS scores decreased during follow-up. Patients who scored higher on the agreeableness personality dimension, despite similar total duration of disease, had higher QOL at the beginning of the follow-up period but the reduction of QOL over time was significantly steeper than in patients who scored lower on agreeableness, associated with faster disease progression. These findings suggest that being less agreeable might serve as a protective factor with respect to QOL and disease progression in ALS.
AB - We aimed to perform a prospective long-term follow-up of health-related quality of life (QOL) in ALS and to investigate the relationship of personality factors with changes in QOL and disease progression.Data on QOL were collected prospectively for 12 months from 31 ALS patients. Personality factors were studied using the NEO-FFI (NEO Five Factor Inventory). Monthly self-ratings of global QOL, and seven health-related QOL functions, as well as ALSFRS (ALS Functional Rating Scale) scores were analyzed using a linear mixed model approach. QOL and ALSFRS scores decreased during follow-up. Patients who scored higher on the agreeableness personality dimension, despite similar total duration of disease, had higher QOL at the beginning of the follow-up period but the reduction of QOL over time was significantly steeper than in patients who scored lower on agreeableness, associated with faster disease progression. These findings suggest that being less agreeable might serve as a protective factor with respect to QOL and disease progression in ALS.
KW - Agreeableness
KW - Amyotrophic lateral sclerosis (ALS)
KW - Five-factor model of personality
KW - Health-related quality of life
KW - Outcome research
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U2 - 10.1080/17482960701875805
DO - 10.1080/17482960701875805
M3 - Article
C2 - 18428002
AN - SCOPUS:42549107552
SN - 1748-2968
VL - 9
SP - 99
EP - 107
JO - Amyotrophic Lateral Sclerosis
JF - Amyotrophic Lateral Sclerosis
IS - 2
ER -