5 Scopus citations

Abstract

Malaria is the vector-transmitted disease that causes the highest morbidity and mortality in humans. Motivated by the known influence of sickle-cell anemia on the morbidity and mortality of malaria-infected humans, we study the effect of malaria on the genetic composition of a host (human) population where sickle-cell anemia is prevalent and malaria is endemic. The host subpopulations are therefore classified according to three genotypes, AA, AS, and SS. It is known that AA malaria-infected individuals experience higher malaria-induced mortality than AS or SS individuals. However, individuals carrying the S gene are known to experience a higher mortality rate in a malaria-free environment than those who lack such a gene. The tradeoffs between increased fitness for some types in the presence of disease (a population level process) and reduced fitness in a disease-free environment are explored in this manuscript. We start from the published results of an earlier model and proceed to remove some model restrictions in order to better understand the impact on the natural hosts' genetics in an environment where malaria is endemic.

Original languageEnglish (US)
Pages (from-to)467-483
Number of pages17
JournalMathematical Biosciences and Engineering
Volume3
Issue number3
DOIs
StatePublished - Jul 2006

Keywords

  • Fast and slow dynamics
  • Infectious diseases
  • Mathematical model
  • Population genetics

ASJC Scopus subject areas

  • Modeling and Simulation
  • Agricultural and Biological Sciences(all)
  • Computational Mathematics
  • Applied Mathematics

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