The influence of geometrically configured sol-gel derived hydroxyapatite substrates on osteoblast response

Daniel Adams; Regina D. Smith; Gerald F. Malgas; Stephen Massia; Terry Alford; J. W. Mayer

doi:10.4028/0-87849-961-x.569

The influence of geometrically configured sol-gel derived hydroxyapatite substrates on osteoblast response

Daniel Adams, Regina D. Smith, Gerald F. Malgas, Stephen Massia, Terry Alford, J. W. Mayer

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Good quality crystalline sol-derived Hydroxyapatite (HA) thin films of thickness ∼350 nm on titanium substrates with underlying micro-channels were prepared by microwave annealing at a temperature of 400°C for 30 min. A comprehensive in-vitro study was conducted to assess the osteoblast adhesive response to the well-defined micro-scale topographical features on HA coated and uncoated surfaces. The study confirmed the osteoblast's response to the HA coated micro-channels with an elongated morphology. The effects to morphology suggest that osteoblast adhesion can be improved through optimal micro-channel design and may provide baseline design cues for improving the long-term performance of prosthetic orthopedic and dental implants.

Original language	English (US)
Pages (from-to)	569-572
Number of pages	4
Journal	Key Engineering Materials
Volume	284-286
DOIs	https://doi.org/10.4028/0-87849-961-x.569
State	Published - 2005

Keywords

Hydroxyapatite
Microwave annealing
Osteoblasts
Topographical features

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.4028/0-87849-961-x.569

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title = "The influence of geometrically configured sol-gel derived hydroxyapatite substrates on osteoblast response",

abstract = "Good quality crystalline sol-derived Hydroxyapatite (HA) thin films of thickness ∼350 nm on titanium substrates with underlying micro-channels were prepared by microwave annealing at a temperature of 400°C for 30 min. A comprehensive in-vitro study was conducted to assess the osteoblast adhesive response to the well-defined micro-scale topographical features on HA coated and uncoated surfaces. The study confirmed the osteoblast's response to the HA coated micro-channels with an elongated morphology. The effects to morphology suggest that osteoblast adhesion can be improved through optimal micro-channel design and may provide baseline design cues for improving the long-term performance of prosthetic orthopedic and dental implants.",

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AU - Adams, Daniel

AU - Smith, Regina D.

AU - Malgas, Gerald F.

AU - Massia, Stephen

AU - Alford, Terry

AU - Mayer, J. W.

PY - 2005

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N2 - Good quality crystalline sol-derived Hydroxyapatite (HA) thin films of thickness ∼350 nm on titanium substrates with underlying micro-channels were prepared by microwave annealing at a temperature of 400°C for 30 min. A comprehensive in-vitro study was conducted to assess the osteoblast adhesive response to the well-defined micro-scale topographical features on HA coated and uncoated surfaces. The study confirmed the osteoblast's response to the HA coated micro-channels with an elongated morphology. The effects to morphology suggest that osteoblast adhesion can be improved through optimal micro-channel design and may provide baseline design cues for improving the long-term performance of prosthetic orthopedic and dental implants.

AB - Good quality crystalline sol-derived Hydroxyapatite (HA) thin films of thickness ∼350 nm on titanium substrates with underlying micro-channels were prepared by microwave annealing at a temperature of 400°C for 30 min. A comprehensive in-vitro study was conducted to assess the osteoblast adhesive response to the well-defined micro-scale topographical features on HA coated and uncoated surfaces. The study confirmed the osteoblast's response to the HA coated micro-channels with an elongated morphology. The effects to morphology suggest that osteoblast adhesion can be improved through optimal micro-channel design and may provide baseline design cues for improving the long-term performance of prosthetic orthopedic and dental implants.

KW - Hydroxyapatite

KW - Microwave annealing

KW - Osteoblasts

KW - Topographical features

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The influence of geometrically configured sol-gel derived hydroxyapatite substrates on osteoblast response

Abstract

Keywords

ASJC Scopus subject areas

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