The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays

Sarah E. Mennenga, Heather Bimonte-Nelson

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Reproductive hormones such as estrogens, androgens, progesterone, and others are responsible for the regulation of countless body functions in addition to their well-known control over reproductive function and behavior. The list of processes governed by internal hormonal secretions is extensive and, as such, hormonal fluctuations influence how animals perform on many established behavioral measures. Additionally, their pervasive impact can alter the way that non-hormonal drug treatments act across individuals. Male reproductive hormones are relatively stable for most of the young adult life span, and, because of this, males tend to demonstrate less variability in behavioral and physiological assessments. This stability is tempting to focus upon when investigating the behavioral effects of a new therapeutic; however, it has become increasingly clear that the effects of pharmaceutical and other manipulations can depend on the background hormone milieu of the individual. Understanding interactions with hormones is vital for the optimization of any potential or existing therapeutic and, therefore, the inclusion of measures outlined in this chapter should be considered when designing rodent behavior studies for this purpose. This chapter discusses the reproductive system and hormonal profiles of male and female rodents, how these hormonal profiles impact commonly used behavioral evaluations, and techniques for monitoring and manipulating these hormone levels, to produce optimal behavioral assessments in rodents.

Original languageEnglish (US)
Title of host publicationThe Maze Book
Subtitle of host publicationTheories, Practice, and Protocols for Testing Rodent Cognition
PublisherSpringer New York
Pages299-321
Number of pages23
ISBN (Electronic)9781493921591
ISBN (Print)9781493921584
DOIs
StatePublished - Mar 10 2015

Fingerprint

Rodentia
rodents
hormones
Hormones
gender
assays
Reproductive Behavior
therapeutics
reproductive system
androgens
young adults
Pharmaceutical Preparations
Androgens
drug therapy
estrogens
Progesterone
Young Adult
progesterone
Estrogens
Therapeutics

Keywords

  • Androgen
  • Behavior
  • Brain
  • Estrogen
  • Experimental design
  • Hormone
  • Learning
  • Memory
  • Mouse
  • Physiology
  • Progesterone
  • Rat
  • Sex
  • Testosterone

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Mennenga, S. E., & Bimonte-Nelson, H. (2015). The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays. In The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition (pp. 299-321). Springer New York. https://doi.org/10.1007/978-1-4939-2159-1_11

The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays. / Mennenga, Sarah E.; Bimonte-Nelson, Heather.

The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition. Springer New York, 2015. p. 299-321.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mennenga, SE & Bimonte-Nelson, H 2015, The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays. in The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition. Springer New York, pp. 299-321. https://doi.org/10.1007/978-1-4939-2159-1_11
Mennenga SE, Bimonte-Nelson H. The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays. In The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition. Springer New York. 2015. p. 299-321 https://doi.org/10.1007/978-1-4939-2159-1_11
Mennenga, Sarah E. ; Bimonte-Nelson, Heather. / The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays. The Maze Book: Theories, Practice, and Protocols for Testing Rodent Cognition. Springer New York, 2015. pp. 299-321
@inbook{a6b78c3a2e504853bb0e2239d1d3b731,
title = "The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays",
abstract = "Reproductive hormones such as estrogens, androgens, progesterone, and others are responsible for the regulation of countless body functions in addition to their well-known control over reproductive function and behavior. The list of processes governed by internal hormonal secretions is extensive and, as such, hormonal fluctuations influence how animals perform on many established behavioral measures. Additionally, their pervasive impact can alter the way that non-hormonal drug treatments act across individuals. Male reproductive hormones are relatively stable for most of the young adult life span, and, because of this, males tend to demonstrate less variability in behavioral and physiological assessments. This stability is tempting to focus upon when investigating the behavioral effects of a new therapeutic; however, it has become increasingly clear that the effects of pharmaceutical and other manipulations can depend on the background hormone milieu of the individual. Understanding interactions with hormones is vital for the optimization of any potential or existing therapeutic and, therefore, the inclusion of measures outlined in this chapter should be considered when designing rodent behavior studies for this purpose. This chapter discusses the reproductive system and hormonal profiles of male and female rodents, how these hormonal profiles impact commonly used behavioral evaluations, and techniques for monitoring and manipulating these hormone levels, to produce optimal behavioral assessments in rodents.",
keywords = "Androgen, Behavior, Brain, Estrogen, Experimental design, Hormone, Learning, Memory, Mouse, Physiology, Progesterone, Rat, Sex, Testosterone",
author = "Mennenga, {Sarah E.} and Heather Bimonte-Nelson",
year = "2015",
month = "3",
day = "10",
doi = "10.1007/978-1-4939-2159-1_11",
language = "English (US)",
isbn = "9781493921584",
pages = "299--321",
booktitle = "The Maze Book",
publisher = "Springer New York",
address = "United States",

}

TY - CHAP

T1 - The importance of incorporating both sexes and embracing hormonal diversity when conducting rodent behavioral assays

AU - Mennenga, Sarah E.

AU - Bimonte-Nelson, Heather

PY - 2015/3/10

Y1 - 2015/3/10

N2 - Reproductive hormones such as estrogens, androgens, progesterone, and others are responsible for the regulation of countless body functions in addition to their well-known control over reproductive function and behavior. The list of processes governed by internal hormonal secretions is extensive and, as such, hormonal fluctuations influence how animals perform on many established behavioral measures. Additionally, their pervasive impact can alter the way that non-hormonal drug treatments act across individuals. Male reproductive hormones are relatively stable for most of the young adult life span, and, because of this, males tend to demonstrate less variability in behavioral and physiological assessments. This stability is tempting to focus upon when investigating the behavioral effects of a new therapeutic; however, it has become increasingly clear that the effects of pharmaceutical and other manipulations can depend on the background hormone milieu of the individual. Understanding interactions with hormones is vital for the optimization of any potential or existing therapeutic and, therefore, the inclusion of measures outlined in this chapter should be considered when designing rodent behavior studies for this purpose. This chapter discusses the reproductive system and hormonal profiles of male and female rodents, how these hormonal profiles impact commonly used behavioral evaluations, and techniques for monitoring and manipulating these hormone levels, to produce optimal behavioral assessments in rodents.

AB - Reproductive hormones such as estrogens, androgens, progesterone, and others are responsible for the regulation of countless body functions in addition to their well-known control over reproductive function and behavior. The list of processes governed by internal hormonal secretions is extensive and, as such, hormonal fluctuations influence how animals perform on many established behavioral measures. Additionally, their pervasive impact can alter the way that non-hormonal drug treatments act across individuals. Male reproductive hormones are relatively stable for most of the young adult life span, and, because of this, males tend to demonstrate less variability in behavioral and physiological assessments. This stability is tempting to focus upon when investigating the behavioral effects of a new therapeutic; however, it has become increasingly clear that the effects of pharmaceutical and other manipulations can depend on the background hormone milieu of the individual. Understanding interactions with hormones is vital for the optimization of any potential or existing therapeutic and, therefore, the inclusion of measures outlined in this chapter should be considered when designing rodent behavior studies for this purpose. This chapter discusses the reproductive system and hormonal profiles of male and female rodents, how these hormonal profiles impact commonly used behavioral evaluations, and techniques for monitoring and manipulating these hormone levels, to produce optimal behavioral assessments in rodents.

KW - Androgen

KW - Behavior

KW - Brain

KW - Estrogen

KW - Experimental design

KW - Hormone

KW - Learning

KW - Memory

KW - Mouse

KW - Physiology

KW - Progesterone

KW - Rat

KW - Sex

KW - Testosterone

UR - http://www.scopus.com/inward/record.url?scp=85025124878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025124878&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-2159-1_11

DO - 10.1007/978-1-4939-2159-1_11

M3 - Chapter

AN - SCOPUS:85025124878

SN - 9781493921584

SP - 299

EP - 321

BT - The Maze Book

PB - Springer New York

ER -