The impact of vaccines and vaccinations: Challenges and opportunities for modelers

Roy Curtiss

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

This review focuses on how infectious diseases and their prevention and control by development of vaccines and widespread vaccination has shaped evolution of human civilization and of the animals and plants that humans depend on for food, labor and companionship. After describing major infectious diseases and the current status for control by vaccination, the barriers to infection and the attributes of innate and acquired immunity contributing to control are discussed. The evolution in types of vaccines is presented in the context of developing technologies and in improving adjuvants to engender enhanced vaccine efficacy. The special concerns and needs in vaccine design and development are discussed in dealing with epidemics/pandemics with special emphasis on influenza and current global problems in vaccine delivery.

Original languageEnglish (US)
Pages (from-to)77-93
Number of pages17
JournalMathematical Biosciences and Engineering
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • Immunity
  • Vaccination
  • Vaccine design
  • Vaccines

ASJC Scopus subject areas

  • Modeling and Simulation
  • Agricultural and Biological Sciences(all)
  • Computational Mathematics
  • Applied Mathematics

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