The impact of stage, grade, and mucinous histology on the efficacy of systemic chemotherapy in adenocarcinomas of the appendix: Analysis of the National Cancer Data Base

Elliot A. Asare, Carolyn Compton, Nader N. Hanna, Lauren A. Kosinski, Mary Kay Washington, Sanjay Kakar, Martin R. Weiser, Michael J. Overman

Research output: Contribution to journalArticle

40 Scopus citations


BACKGROUND Adenocarcinomas of the appendix represent a heterogeneous disease depending on the presence of mucinous histology, histologic grade, and stage. In the current study, the authors sought to explore the interplay of these factors with systemic chemotherapy in a large population data set. METHODS Patients in the National Cancer Data Base (NCDB) who were diagnosed with mucinous, nonmucinous, and signet ring cell-type appendiceal neoplasms from 1985 through 2006 were selected. Multivariable Cox proportional hazards regression models were developed. RESULTS A total of 11,871 patients met the inclusion criteria for the current study: 50.3% had mucinous neoplasms, 40.5% had nonmucinous neoplasms, and 9.2% had signet ring cell-type neoplasms. The 5-year overall survival (OS) stratified by grade was similar among patients with American Joint Committee on Cancer stage I to stage III disease but not for those with stage IV disease. The median OS for patients with stage IV mucinous and nonmucinous tumors was 6.4 years and 2.3 years, respectively, for those with well differentiated histology (P

Original languageEnglish (US)
Pages (from-to)213-221
Number of pages9
Issue number2
StatePublished - Jan 15 2016



  • appendix
  • chemotherapy
  • mucinous
  • nonmucinous
  • survival

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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