The impact of simultaneous pancreas-kidney transplantation on long-term patient survival

Akinlolu O. Ojo, Herwig Ulf Meier-Kriesche, Julie A. Hanson, Alan Leichtman, John C. Magee, Diane Cibrik, Robert A. Wolfe, Friedrich K. Port, Lawrence Agodoa, Dixon B. Kaufman, Bruce Kaplan

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

Background. Simultaneous pancreas-kidney transplantation (SPK) ameliorates the progression of microvascular diabetic complications but the procedure is associated with excess initial morbidity and an uncertain effect on patient survival when compared with solitary cadaveric or living donor renal transplantation. We evaluated mortality risks associated with SPK, solitary renal transplantation, and dialysis treatment in a national cohort of type I diabetics with end-stage nephropathy. Methods. A total of 13,467 adult-type 1 diabetics enrolled on the renal and renal-pancreas transplant waiting list between 10/01/88 and 06/30/97 were followed until 06/30/98. Time-dependent mortality risks and life expectancy were calculated according to the treatment received subsequent to wait-list registration: SPK; cadaveric kidney only (CAD); living donor kidney only (LKD) transplantation; and dialysis [waitlisted, maintenance dialysis treatment (WLD)]. Results. Adjusted 10-year patient survival was 67% for SPK vs. 65% for LKD recipients (P=0.19) ad 46% for CAD recipients (P

Original languageEnglish (US)
Pages (from-to)82-90
Number of pages9
JournalTransplantation
Volume71
Issue number1
StatePublished - Jan 15 2001
Externally publishedYes

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Pancreas Transplantation
Kidney Transplantation
Survival
Kidney
Living Donors
Dialysis
Waiting Lists
Mortality
Diabetes Complications
Life Expectancy
Renal Dialysis
Pancreas
Therapeutics
Transplantation
Maintenance
Morbidity
Transplants

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Ojo, A. O., Meier-Kriesche, H. U., Hanson, J. A., Leichtman, A., Magee, J. C., Cibrik, D., ... Kaplan, B. (2001). The impact of simultaneous pancreas-kidney transplantation on long-term patient survival. Transplantation, 71(1), 82-90.

The impact of simultaneous pancreas-kidney transplantation on long-term patient survival. / Ojo, Akinlolu O.; Meier-Kriesche, Herwig Ulf; Hanson, Julie A.; Leichtman, Alan; Magee, John C.; Cibrik, Diane; Wolfe, Robert A.; Port, Friedrich K.; Agodoa, Lawrence; Kaufman, Dixon B.; Kaplan, Bruce.

In: Transplantation, Vol. 71, No. 1, 15.01.2001, p. 82-90.

Research output: Contribution to journalArticle

Ojo, AO, Meier-Kriesche, HU, Hanson, JA, Leichtman, A, Magee, JC, Cibrik, D, Wolfe, RA, Port, FK, Agodoa, L, Kaufman, DB & Kaplan, B 2001, 'The impact of simultaneous pancreas-kidney transplantation on long-term patient survival', Transplantation, vol. 71, no. 1, pp. 82-90.
Ojo AO, Meier-Kriesche HU, Hanson JA, Leichtman A, Magee JC, Cibrik D et al. The impact of simultaneous pancreas-kidney transplantation on long-term patient survival. Transplantation. 2001 Jan 15;71(1):82-90.
Ojo, Akinlolu O. ; Meier-Kriesche, Herwig Ulf ; Hanson, Julie A. ; Leichtman, Alan ; Magee, John C. ; Cibrik, Diane ; Wolfe, Robert A. ; Port, Friedrich K. ; Agodoa, Lawrence ; Kaufman, Dixon B. ; Kaplan, Bruce. / The impact of simultaneous pancreas-kidney transplantation on long-term patient survival. In: Transplantation. 2001 ; Vol. 71, No. 1. pp. 82-90.
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