The impact of electrically conductive and non-conductive nanocomposite hydrogels on functionalities of engineered cardiac tissues

Ali Navaei, Mehdi Nikkhah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Developing nanocomposite scaffolds embedded with electrically conductive nanomaterials have been at the center of attention for engineering functional cardiac tissues [1-2]. Previous work in this regard have shown that the incorporation of conductive nanomaterials within the matrix of scaffold led to significantly enhanced maturation and electrical excitability. The enhanced tissue functionalities are attributed to the increased electrical conductivity and mechanical stiffness as well as the induced nano-scale topographies of nanocomposite scaffolds. Despite the significance, what is missing in the literature is whether the sole presence of nanomaterials, regardless of their electrical conductivity, could promote electrical and contractile functionalities among cardiomyocytes (CMs). To address this knowledge gap, in this work, we developed four different classes of nanocomposite scaffolds, embedded with conductive gold nanorods (GNRs) and non-conductive silica nanoparticles (SNPs), to dissect the role of scaffold stiffness and nano-scale topography, from its electrical conductivity, on maturation and excitability of the engineered cardiac tissues.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Navaei, A., & Nikkhah, M. (2019). The impact of electrically conductive and non-conductive nanocomposite hydrogels on functionalities of engineered cardiac tissues. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.