The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

Jia Liu; Sonia Wennier; G. McFadden Grant

doi:10.1016/j.micinf.2010.08.012

The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

Jia Liu, Sonia Wennier, G. McFadden Grant

Research output: Contribution to journal › Short survey › peer-review

32 Scopus citations

Abstract

Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.

Original language	English (US)
Pages (from-to)	1144-1152
Number of pages	9
Journal	Microbes and Infection
Volume	12
Issue number	14-15
DOIs	https://doi.org/10.1016/j.micinf.2010.08.012
State	Published - Dec 2010
Externally published	Yes

Keywords

Immunoregulatory factors
Myxoma virus
Oncolytic virus
Poxvirus

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2010.08.012

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title = "The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics",

abstract = "Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.",

keywords = "Immunoregulatory factors, Myxoma virus, Oncolytic virus, Poxvirus",

author = "Jia Liu and Sonia Wennier and {McFadden Grant}, G.",

year = "2010",

month = dec,

doi = "10.1016/j.micinf.2010.08.012",

language = "English (US)",

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journal = "Microbes and Infection",

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TY - JOUR

T1 - The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

AU - Liu, Jia

AU - Wennier, Sonia

AU - McFadden Grant, G.

PY - 2010/12

Y1 - 2010/12

N2 - Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.

AB - Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.

KW - Immunoregulatory factors

KW - Myxoma virus

KW - Oncolytic virus

KW - Poxvirus

UR - http://www.scopus.com/inward/record.url?scp=78649811429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649811429&partnerID=8YFLogxK

U2 - 10.1016/j.micinf.2010.08.012

DO - 10.1016/j.micinf.2010.08.012

M3 - Short survey

C2 - 20832500

AN - SCOPUS:78649811429

SN - 1286-4579

VL - 12

SP - 1144

EP - 1152

JO - Microbes and Infection

JF - Microbes and Infection

IS - 14-15

ER -

The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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