The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

Jia Liu, Sonia Wennier, G. McFadden Grant

Research output: Contribution to journalShort surveypeer-review

28 Scopus citations

Abstract

Myxoma virus (MYXV) is a poxvirus with a strict rabbit-specific host-tropism for pathogenesis. The immunoregulatory factors encoded by MYXV can suppress some functions of immune effectors from other species. We review their mechanisms of action, implications in therapeutics and the potential to improve MYXV as an oncolytic agent in humans.

Original languageEnglish (US)
Pages (from-to)1144-1152
Number of pages9
JournalMicrobes and Infection
Volume12
Issue number14-15
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Immunoregulatory factors
  • Myxoma virus
  • Oncolytic virus
  • Poxvirus

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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