Abstract
Background: Elevated plasma triglycerides (TG) and waist girth (hypertriglyceridemic waist (HTGW)) has been associated with elevated insulin, small dense low-density lipoprotein (sLDL) particles, and Apo B in men. The HTGW has not been reported for women and the effect of cardiorespiratory fitness ("fitness") on associations between HTGW and coronary risk factors is unknown. Purpose: To determine the prevalence of HTGW and the influence of fitness on the relationship between HTGW and coronary risk among 137 healthy women (54±9 year; body mass index (BMI)=28±6kg/m 2). Methods: HTGW was defined as waist girth >88cm and TG >150mg/dl. The metabolic triad was defined as insulin >31pmol/l, Apo B >69mg/dl and LDL-C >84mg/dl. Fitness was assessed with a maximal treadmill exercise test. Results: The sample prevalence of HTGW (n=15) was 11% (95% CI=5.7-16.0%). Apo B (P=0.04) and insulin (P=0.0001) increased across quintiles of waist girth, and LDL-C (P=0.004) increased across quintiles of TG. Metabolic triad prevalence was highest (67%, n=10) among HTGW women and lowest (22%, n=26) among non-HTGW women. A trend for higher coronary heart disease CHD risk factors was observed among HTGW compared with non-HTGW women. Among the HTGW group, a trend for lower CHD risk factors was observed among fit (≥6.5METs, n=7) versus unfit women (<6.5METs, n=8). Sample size limitations prohibited meaningful tests of significant differences in CHD risk factors when stratified simultaneously on HTGW and fitness status. Conclusions: HTGW is associated with increased coronary risk factors similarly among women as reported for men. Higher fitness may improve the CHD risk profile among women with HTGW.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 123-130 |
| Number of pages | 8 |
| Journal | Atherosclerosis |
| Volume | 171 |
| Issue number | 1 |
| DOIs | |
| State | Published - Nov 2003 |
| Externally published | Yes |
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Keywords
- Cardiovascular disease
- Exercise
- Lipids
- Obesity
- Women
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
The hypertriglyceridemic waist phenotype among women. / LaMonte, Michael J.; Ainsworth, Barbara; DuBose, Katrina D.; Grandjean, Peter W.; Davis, Paul G.; Yanowitz, Frank G.; Durstine, J. Larry.
In: Atherosclerosis, Vol. 171, No. 1, 11.2003, p. 123-130.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The hypertriglyceridemic waist phenotype among women
AU - LaMonte, Michael J.
AU - Ainsworth, Barbara
AU - DuBose, Katrina D.
AU - Grandjean, Peter W.
AU - Davis, Paul G.
AU - Yanowitz, Frank G.
AU - Durstine, J. Larry
PY - 2003/11
Y1 - 2003/11
N2 - Background: Elevated plasma triglycerides (TG) and waist girth (hypertriglyceridemic waist (HTGW)) has been associated with elevated insulin, small dense low-density lipoprotein (sLDL) particles, and Apo B in men. The HTGW has not been reported for women and the effect of cardiorespiratory fitness ("fitness") on associations between HTGW and coronary risk factors is unknown. Purpose: To determine the prevalence of HTGW and the influence of fitness on the relationship between HTGW and coronary risk among 137 healthy women (54±9 year; body mass index (BMI)=28±6kg/m 2). Methods: HTGW was defined as waist girth >88cm and TG >150mg/dl. The metabolic triad was defined as insulin >31pmol/l, Apo B >69mg/dl and LDL-C >84mg/dl. Fitness was assessed with a maximal treadmill exercise test. Results: The sample prevalence of HTGW (n=15) was 11% (95% CI=5.7-16.0%). Apo B (P=0.04) and insulin (P=0.0001) increased across quintiles of waist girth, and LDL-C (P=0.004) increased across quintiles of TG. Metabolic triad prevalence was highest (67%, n=10) among HTGW women and lowest (22%, n=26) among non-HTGW women. A trend for higher coronary heart disease CHD risk factors was observed among HTGW compared with non-HTGW women. Among the HTGW group, a trend for lower CHD risk factors was observed among fit (≥6.5METs, n=7) versus unfit women (<6.5METs, n=8). Sample size limitations prohibited meaningful tests of significant differences in CHD risk factors when stratified simultaneously on HTGW and fitness status. Conclusions: HTGW is associated with increased coronary risk factors similarly among women as reported for men. Higher fitness may improve the CHD risk profile among women with HTGW.
AB - Background: Elevated plasma triglycerides (TG) and waist girth (hypertriglyceridemic waist (HTGW)) has been associated with elevated insulin, small dense low-density lipoprotein (sLDL) particles, and Apo B in men. The HTGW has not been reported for women and the effect of cardiorespiratory fitness ("fitness") on associations between HTGW and coronary risk factors is unknown. Purpose: To determine the prevalence of HTGW and the influence of fitness on the relationship between HTGW and coronary risk among 137 healthy women (54±9 year; body mass index (BMI)=28±6kg/m 2). Methods: HTGW was defined as waist girth >88cm and TG >150mg/dl. The metabolic triad was defined as insulin >31pmol/l, Apo B >69mg/dl and LDL-C >84mg/dl. Fitness was assessed with a maximal treadmill exercise test. Results: The sample prevalence of HTGW (n=15) was 11% (95% CI=5.7-16.0%). Apo B (P=0.04) and insulin (P=0.0001) increased across quintiles of waist girth, and LDL-C (P=0.004) increased across quintiles of TG. Metabolic triad prevalence was highest (67%, n=10) among HTGW women and lowest (22%, n=26) among non-HTGW women. A trend for higher coronary heart disease CHD risk factors was observed among HTGW compared with non-HTGW women. Among the HTGW group, a trend for lower CHD risk factors was observed among fit (≥6.5METs, n=7) versus unfit women (<6.5METs, n=8). Sample size limitations prohibited meaningful tests of significant differences in CHD risk factors when stratified simultaneously on HTGW and fitness status. Conclusions: HTGW is associated with increased coronary risk factors similarly among women as reported for men. Higher fitness may improve the CHD risk profile among women with HTGW.
KW - Cardiovascular disease
KW - Exercise
KW - Lipids
KW - Obesity
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=0344420091&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0344420091&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2003.07.008
DO - 10.1016/j.atherosclerosis.2003.07.008
M3 - Article
C2 - 14642414
AN - SCOPUS:0344420091
VL - 171
SP - 123
EP - 130
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -