The growth and cytopathogenicity of virulent and attenuated strains of canine distemper virus in dog and ferret macrophages

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The in vitro growth of virulent and attenuated strains of canine distemper virus in dog and ferret lung, liver, spleen and peritoneal macrophages was examined. All virus strains tested grew in each type of macrophage culture. Cytopathic effects, consisting of cytoplasmic and nuclear inclusion bodies and polykaryocytosis, were found in all virus-cell combinations. The polykaryocytes were formed both by cell fusion and from single cells by amitosis. Marked nuclear abnormalities were found in alveolar macrophages infected with virulent virus strains. The role of lysosomal enzymes in the development of these cytopathic effects was discussed.

Original languageEnglish (US)
Pages (from-to)49-54,IN11-IN12
JournalJournal of Comparative Pathology
Volume81
Issue number1
DOIs
StatePublished - Jan 1971
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • veterinary(all)

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