The genetic structure of native Americans in North America based on the Globalfiler® STRs

Kelly L. McCulloh, Jillian Ng, Robert F. Oldt, Jessica A. Weise, Joy Viray, Bruce Budowle, David Glenn Smith, Sreetharan Kanthaswamy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Current forensic STR databases, such as CODIS, lack population genetic data on Native American populations. Information from a geographically diverse array of tribes is necessary to provide improved statistical estimates of the strength of associations with DNA evidence. The Globalfiler® STR markers were used to characterize the genetic structure of ten tribal populations from seven geographic regions in North America, including those not presently represented in forensic databases. Samples from the Arctic region, Baja California, California/Great Basin, the Southeast, Mexico, the Midwest, and the Southwest were analyzed for allele frequencies, observed and expected heterozygosities, and F-statistics. The tribal samples exhibited an FST or θ value above the conservative 0.03 estimate recommended by the National Research Council (NRC) for calculating random match probabilities among Native Americans. The greater differentiation among tribal populations computed here (θ = 0.04) warrants the inclusion of additional regional Native American samples into STR databases.

Original languageEnglish (US)
Pages (from-to)49-54
Number of pages6
JournalLegal Medicine
Volume23
DOIs
StatePublished - Nov 1 2016
Externally publishedYes

Fingerprint

North American Indians
Genetic Structures
North America
Databases
Arctic Regions
Population
Population Genetics
Mexico
Population Groups
Gene Frequency
DNA

Keywords

  • Forensic science
  • Geography
  • Native Americans
  • North America
  • Population genetics
  • Short tandem repeats

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects

Cite this

The genetic structure of native Americans in North America based on the Globalfiler® STRs. / McCulloh, Kelly L.; Ng, Jillian; Oldt, Robert F.; Weise, Jessica A.; Viray, Joy; Budowle, Bruce; Glenn Smith, David; Kanthaswamy, Sreetharan.

In: Legal Medicine, Vol. 23, 01.11.2016, p. 49-54.

Research output: Contribution to journalArticle

McCulloh, Kelly L. ; Ng, Jillian ; Oldt, Robert F. ; Weise, Jessica A. ; Viray, Joy ; Budowle, Bruce ; Glenn Smith, David ; Kanthaswamy, Sreetharan. / The genetic structure of native Americans in North America based on the Globalfiler® STRs. In: Legal Medicine. 2016 ; Vol. 23. pp. 49-54.
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