The genetic architecture of immune defense and reproduction in male Bombus terrestris bumblebees

Lena Wilfert, Juergen Gadau, Paul Schmid-Hempel

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Understanding the architecture of genetic variation, that is the number, effect, location, and interaction, of genes responsible for phenotypic variability in nature is important for the understanding of microevolutionary processes. In this study, we have used a quantitative trait loci (QTL) approach to uncover the genetic architecture of fitness-relevant traits associated with reproduction and immune defense in male Bombus terrestris bumblebees. Three male reproductive investment traits, the number and length of the produced sperm and the size of the accessory glands, were studied. Two branches of the insect innate immune system, the activation of the Phenoloxidase-cascade and the hemolymph's antibacterial activity, were investigated. We found that variation in most of the studied traits is based on a network of minor QTLs and epistatic interactions. Unexpectedly, there was no evidence for phenotypic or genetic trade-offs between the presumably costly investment in immune defense and reproductive effort in this population for the measured traits. In fact, we found a positive correlation, both, in phenotype and genetic architecture for the number of produced sperm and antibacterial activity against an insect pathogen. A major finding for all traits analyzed was that the epistatic interactions accounted for a major proportion of the explained phenotypic variance. Especially for traits involved in immune defense, this pattern highlights the possible role of parasites in the evolution and maintenance of recombination and sexual reproduction.

Original languageEnglish (US)
Pages (from-to)804-815
Number of pages12
JournalEvolution
Volume61
Issue number4
DOIs
StatePublished - Apr 2007

Fingerprint

Bombus terrestris
Bombus
Reproduction
Insects
Genetic Fitness
sperm
Sperm Count
Monophenol Monooxygenase
Hemolymph
Quantitative Trait Loci
quantitative trait loci
spermatozoa
insect
Genetic Recombination
Spermatozoa
Immune System
Parasites
entomopathogens
gene interaction
reproductive effort

Keywords

  • Epistasis
  • Natural variation
  • QTL
  • Recombination
  • Trade-off

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Genetics(clinical)
  • Ecology
  • Genetics

Cite this

The genetic architecture of immune defense and reproduction in male Bombus terrestris bumblebees. / Wilfert, Lena; Gadau, Juergen; Schmid-Hempel, Paul.

In: Evolution, Vol. 61, No. 4, 04.2007, p. 804-815.

Research output: Contribution to journalArticle

Wilfert, Lena ; Gadau, Juergen ; Schmid-Hempel, Paul. / The genetic architecture of immune defense and reproduction in male Bombus terrestris bumblebees. In: Evolution. 2007 ; Vol. 61, No. 4. pp. 804-815.
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