The experimental and clinical implications of cellular heterogeneity in malignant tumors

George Poste, R. Greig

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The growing body of evidence showing that malignant tumors are heterogeneous and contain diverse subpopulations of tumor cells is reviewed, with particular emphasis being given to the presence of tumor-cell subpopulations with differing metastatic properties. The factors that may influence the evolution of cellular diversity at different stages in the progression of malignant neoplasms are discussed. Emphasis is given to the possibility that interactions occurring amongst the constituent subpopulations of a malignant tumor may influence the rate at which new variant subpopulations emerge. Metastatic heterogeneity poses significant problems for experimental efforts to identify features unique to metastatic cells and also for the therapy of metastatic disease.

Original languageEnglish (US)
Pages (from-to)159-170
Number of pages12
JournalJournal of Cancer Research and Clinical Oncology
Volume106
Issue number3
DOIs
StatePublished - Dec 1983
Externally publishedYes

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Neoplasms
Cell- and Tissue-Based Therapy

Keywords

  • Cancer
  • Cellular interactions
  • Chemotherapy
  • Phenotypic regulation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The experimental and clinical implications of cellular heterogeneity in malignant tumors. / Poste, George; Greig, R.

In: Journal of Cancer Research and Clinical Oncology, Vol. 106, No. 3, 12.1983, p. 159-170.

Research output: Contribution to journalArticle

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