The evolutionary history of plasmodium vivax as inferred from mitochondrial genomes

Parasite genetic diversity in the Americas

Jesse E. Taylor, M. Andreína Pacheco, David J. Bacon, Mohammad A. Beg, Ricardo Luiz MacHado, Rick M. Fairhurst, Socrates Herrera, Jung Yeon Kim, Didier Menard, Marinete Marins Póvoa, Leopoldo Villegas, Mulyanto, Georges Snounou, Liwang Cui, Fadile Yildiz Zeyrek, Ananias A. Escalante

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Plasmodium vivax is the most prevalent human malaria parasite in the Americas. Previous studies have contrasted the genetic diversity of parasite populations in the Americas with those in Asia and Oceania, concluding that New World populations exhibit low genetic diversity consistent with a recent introduction. Here we used an expanded sample of complete mitochondrial genome sequences to investigate the diversity of P. vivax in the Americas as well as in other continental populations. We show that the diversity of P. vivax in the Americas is comparable to that in Asia and Oceania, and we identify several divergent clades circulating in South America that may have resulted from independent introductions. In particular, we show that several haplotypes sampled in Venezuela and northeastern Brazil belong to a clade that diverged from the other P. vivax lineages at least 30,000 years ago, albeit not necessarily in the Americas. We propose that, unlike in Asia where human migration increases local genetic diversity, the combined effects of the geographical structure and the low incidence of vivax malaria in the Americas has resulted in patterns of low local but high regional genetic diversity. This could explain previous views that P. vivax in the Americas has low genetic diversity because these were based on studies carried out in limited areas. Further elucidation of the complex geographical pattern of P. vivax variation will be important both for diversity assessments of genes encoding candidate vaccine antigens and in the formulation of control and surveillance measures aimed at malaria elimination.

Original languageEnglish (US)
Pages (from-to)2050-2064
Number of pages15
JournalMolecular Biology and Evolution
Volume30
Issue number9
DOIs
StatePublished - Sep 2013

Fingerprint

Plasmodium vivax
Mitochondrial Genome
parasite
Parasites
genome
History
parasites
genetic variation
history
malaria
Oceania
Pacific Ocean Islands
Malaria
Human Migration
Population
Vivax Malaria
Venezuela
South America
vaccine
mitochondrial genome

Keywords

  • demographic history
  • molecular clock
  • population structure

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Ecology, Evolution, Behavior and Systematics

Cite this

The evolutionary history of plasmodium vivax as inferred from mitochondrial genomes : Parasite genetic diversity in the Americas. / Taylor, Jesse E.; Pacheco, M. Andreína; Bacon, David J.; Beg, Mohammad A.; MacHado, Ricardo Luiz; Fairhurst, Rick M.; Herrera, Socrates; Kim, Jung Yeon; Menard, Didier; Póvoa, Marinete Marins; Villegas, Leopoldo; Mulyanto; Snounou, Georges; Cui, Liwang; Zeyrek, Fadile Yildiz; Escalante, Ananias A.

In: Molecular Biology and Evolution, Vol. 30, No. 9, 09.2013, p. 2050-2064.

Research output: Contribution to journalArticle

Taylor, JE, Pacheco, MA, Bacon, DJ, Beg, MA, MacHado, RL, Fairhurst, RM, Herrera, S, Kim, JY, Menard, D, Póvoa, MM, Villegas, L, Mulyanto, Snounou, G, Cui, L, Zeyrek, FY & Escalante, AA 2013, 'The evolutionary history of plasmodium vivax as inferred from mitochondrial genomes: Parasite genetic diversity in the Americas', Molecular Biology and Evolution, vol. 30, no. 9, pp. 2050-2064. https://doi.org/10.1093/molbev/mst104
Taylor, Jesse E. ; Pacheco, M. Andreína ; Bacon, David J. ; Beg, Mohammad A. ; MacHado, Ricardo Luiz ; Fairhurst, Rick M. ; Herrera, Socrates ; Kim, Jung Yeon ; Menard, Didier ; Póvoa, Marinete Marins ; Villegas, Leopoldo ; Mulyanto ; Snounou, Georges ; Cui, Liwang ; Zeyrek, Fadile Yildiz ; Escalante, Ananias A. / The evolutionary history of plasmodium vivax as inferred from mitochondrial genomes : Parasite genetic diversity in the Americas. In: Molecular Biology and Evolution. 2013 ; Vol. 30, No. 9. pp. 2050-2064.
@article{2f3e91624d734ddf947cfd94273fe364,
title = "The evolutionary history of plasmodium vivax as inferred from mitochondrial genomes: Parasite genetic diversity in the Americas",
abstract = "Plasmodium vivax is the most prevalent human malaria parasite in the Americas. Previous studies have contrasted the genetic diversity of parasite populations in the Americas with those in Asia and Oceania, concluding that New World populations exhibit low genetic diversity consistent with a recent introduction. Here we used an expanded sample of complete mitochondrial genome sequences to investigate the diversity of P. vivax in the Americas as well as in other continental populations. We show that the diversity of P. vivax in the Americas is comparable to that in Asia and Oceania, and we identify several divergent clades circulating in South America that may have resulted from independent introductions. In particular, we show that several haplotypes sampled in Venezuela and northeastern Brazil belong to a clade that diverged from the other P. vivax lineages at least 30,000 years ago, albeit not necessarily in the Americas. We propose that, unlike in Asia where human migration increases local genetic diversity, the combined effects of the geographical structure and the low incidence of vivax malaria in the Americas has resulted in patterns of low local but high regional genetic diversity. This could explain previous views that P. vivax in the Americas has low genetic diversity because these were based on studies carried out in limited areas. Further elucidation of the complex geographical pattern of P. vivax variation will be important both for diversity assessments of genes encoding candidate vaccine antigens and in the formulation of control and surveillance measures aimed at malaria elimination.",
keywords = "demographic history, molecular clock, population structure",
author = "Taylor, {Jesse E.} and Pacheco, {M. Andre{\'i}na} and Bacon, {David J.} and Beg, {Mohammad A.} and MacHado, {Ricardo Luiz} and Fairhurst, {Rick M.} and Socrates Herrera and Kim, {Jung Yeon} and Didier Menard and P{\'o}voa, {Marinete Marins} and Leopoldo Villegas and Mulyanto and Georges Snounou and Liwang Cui and Zeyrek, {Fadile Yildiz} and Escalante, {Ananias A.}",
year = "2013",
month = "9",
doi = "10.1093/molbev/mst104",
language = "English (US)",
volume = "30",
pages = "2050--2064",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - The evolutionary history of plasmodium vivax as inferred from mitochondrial genomes

T2 - Parasite genetic diversity in the Americas

AU - Taylor, Jesse E.

AU - Pacheco, M. Andreína

AU - Bacon, David J.

AU - Beg, Mohammad A.

AU - MacHado, Ricardo Luiz

AU - Fairhurst, Rick M.

AU - Herrera, Socrates

AU - Kim, Jung Yeon

AU - Menard, Didier

AU - Póvoa, Marinete Marins

AU - Villegas, Leopoldo

AU - Mulyanto,

AU - Snounou, Georges

AU - Cui, Liwang

AU - Zeyrek, Fadile Yildiz

AU - Escalante, Ananias A.

PY - 2013/9

Y1 - 2013/9

N2 - Plasmodium vivax is the most prevalent human malaria parasite in the Americas. Previous studies have contrasted the genetic diversity of parasite populations in the Americas with those in Asia and Oceania, concluding that New World populations exhibit low genetic diversity consistent with a recent introduction. Here we used an expanded sample of complete mitochondrial genome sequences to investigate the diversity of P. vivax in the Americas as well as in other continental populations. We show that the diversity of P. vivax in the Americas is comparable to that in Asia and Oceania, and we identify several divergent clades circulating in South America that may have resulted from independent introductions. In particular, we show that several haplotypes sampled in Venezuela and northeastern Brazil belong to a clade that diverged from the other P. vivax lineages at least 30,000 years ago, albeit not necessarily in the Americas. We propose that, unlike in Asia where human migration increases local genetic diversity, the combined effects of the geographical structure and the low incidence of vivax malaria in the Americas has resulted in patterns of low local but high regional genetic diversity. This could explain previous views that P. vivax in the Americas has low genetic diversity because these were based on studies carried out in limited areas. Further elucidation of the complex geographical pattern of P. vivax variation will be important both for diversity assessments of genes encoding candidate vaccine antigens and in the formulation of control and surveillance measures aimed at malaria elimination.

AB - Plasmodium vivax is the most prevalent human malaria parasite in the Americas. Previous studies have contrasted the genetic diversity of parasite populations in the Americas with those in Asia and Oceania, concluding that New World populations exhibit low genetic diversity consistent with a recent introduction. Here we used an expanded sample of complete mitochondrial genome sequences to investigate the diversity of P. vivax in the Americas as well as in other continental populations. We show that the diversity of P. vivax in the Americas is comparable to that in Asia and Oceania, and we identify several divergent clades circulating in South America that may have resulted from independent introductions. In particular, we show that several haplotypes sampled in Venezuela and northeastern Brazil belong to a clade that diverged from the other P. vivax lineages at least 30,000 years ago, albeit not necessarily in the Americas. We propose that, unlike in Asia where human migration increases local genetic diversity, the combined effects of the geographical structure and the low incidence of vivax malaria in the Americas has resulted in patterns of low local but high regional genetic diversity. This could explain previous views that P. vivax in the Americas has low genetic diversity because these were based on studies carried out in limited areas. Further elucidation of the complex geographical pattern of P. vivax variation will be important both for diversity assessments of genes encoding candidate vaccine antigens and in the formulation of control and surveillance measures aimed at malaria elimination.

KW - demographic history

KW - molecular clock

KW - population structure

UR - http://www.scopus.com/inward/record.url?scp=84881192049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881192049&partnerID=8YFLogxK

U2 - 10.1093/molbev/mst104

DO - 10.1093/molbev/mst104

M3 - Article

VL - 30

SP - 2050

EP - 2064

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 9

ER -