Abstract
Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved. Using information on the levels of protein multimerization in major phylogenetic groups as a guide to the patterns that must be explained and relying on results from population-genetic theory to define the relative plausibility of alternative evolutionary pathways, a framework for understanding the evolution of dimers is developed. The resultant theory demonstrates that the likelihoods of alternative pathways for the emergence of protein complexes depend strongly on the effective population size. Nonetheless, it is equally clear that further advancements in this area will require comparative studies on the fitness consequences of alternative monomeric and dimeric proteins.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1353-1366 |
| Number of pages | 14 |
| Journal | Molecular Biology and Evolution |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2012 |
| Externally published | Yes |
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Keywords
- Complex adaptation
- Dimer
- Genome evolution
- Heteromer
- Molecular evolution
- Random genetic drift
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Molecular Biology
- Genetics
Cite this
The evolution of multimeric protein assemblages. / Lynch, Michael.
In: Molecular Biology and Evolution, Vol. 29, No. 5, 01.05.2012, p. 1353-1366.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The evolution of multimeric protein assemblages
AU - Lynch, Michael
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved. Using information on the levels of protein multimerization in major phylogenetic groups as a guide to the patterns that must be explained and relying on results from population-genetic theory to define the relative plausibility of alternative evolutionary pathways, a framework for understanding the evolution of dimers is developed. The resultant theory demonstrates that the likelihoods of alternative pathways for the emergence of protein complexes depend strongly on the effective population size. Nonetheless, it is equally clear that further advancements in this area will require comparative studies on the fitness consequences of alternative monomeric and dimeric proteins.
AB - Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved. Using information on the levels of protein multimerization in major phylogenetic groups as a guide to the patterns that must be explained and relying on results from population-genetic theory to define the relative plausibility of alternative evolutionary pathways, a framework for understanding the evolution of dimers is developed. The resultant theory demonstrates that the likelihoods of alternative pathways for the emergence of protein complexes depend strongly on the effective population size. Nonetheless, it is equally clear that further advancements in this area will require comparative studies on the fitness consequences of alternative monomeric and dimeric proteins.
KW - Complex adaptation
KW - Dimer
KW - Genome evolution
KW - Heteromer
KW - Molecular evolution
KW - Random genetic drift
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UR - http://www.scopus.com/inward/citedby.url?scp=84862839039&partnerID=8YFLogxK
U2 - 10.1093/molbev/msr300
DO - 10.1093/molbev/msr300
M3 - Article
VL - 29
SP - 1353
EP - 1366
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
SN - 0737-4038
IS - 5
ER -