The evolution of multimeric protein assemblages

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Although the mechanisms by which complex cellular features evolve constitute one of the great unsolved problems of evolutionary biology, it is clear that the emergence of new protein-protein interactions, often accompanied by the diversification of duplicate genes, is involved. Using information on the levels of protein multimerization in major phylogenetic groups as a guide to the patterns that must be explained and relying on results from population-genetic theory to define the relative plausibility of alternative evolutionary pathways, a framework for understanding the evolution of dimers is developed. The resultant theory demonstrates that the likelihoods of alternative pathways for the emergence of protein complexes depend strongly on the effective population size. Nonetheless, it is equally clear that further advancements in this area will require comparative studies on the fitness consequences of alternative monomeric and dimeric proteins.

Original languageEnglish (US)
Pages (from-to)1353-1366
Number of pages14
JournalMolecular Biology and Evolution
Volume29
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

Fingerprint

protein
duplicate genes
Proteins
proteins
Duplicate Genes
Protein Multimerization
protein-protein interactions
population genetics
Population Genetics
Population Dynamics
population size
Population Density
effective population size
evolutionary biology
Biological Sciences
phylogeny
comparative study
fitness
phylogenetics
gene

Keywords

  • Complex adaptation
  • Dimer
  • Genome evolution
  • Heteromer
  • Molecular evolution
  • Random genetic drift

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

The evolution of multimeric protein assemblages. / Lynch, Michael.

In: Molecular Biology and Evolution, Vol. 29, No. 5, 01.05.2012, p. 1353-1366.

Research output: Contribution to journalArticle

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