The epigenetics of Alzheimer's disease - additional considerations

Joseph Rogers, Diego Mastroeni, Andrew Grover, Elaine Delvaux, Charisse Whiteside, Paul D. Coleman

Research output: Contribution to journalComment/debate

7 Scopus citations

Abstract

The critical commentaries following our review of the epigenetics of Alzheimer's disease (AD) amplify a number of key points with respect to the role of 1-carbon metabolism, the phenomenon of allele-specific methylation, the potentially critical explanatory link provided by epigenetic mechanisms for genome-wide association and large-scale gene expression array studies, and new therapeutic approaches afforded by epigenetic manipulation in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)1196-1197
Number of pages2
JournalNeurobiology of Aging
Volume32
Issue number7
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Keywords

  • Aging
  • Alzheimer's disease
  • DNA methylation
  • Epigenetics
  • Histone marks
  • MiRNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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