The epigenetics of aging and neurodegeneration

Roy Lardenoije, Artemis Iatrou, Gunter Kenis, Konstantinos Kompotis, Harry W.M. Steinbusch, Diego Mastroeni, Paul Coleman, Cynthia A. Lemere, Patrick R. Hof, Daniel L.A. van den Hove, Bart P.F. Rutten

Research output: Contribution to journalReview article

139 Citations (Scopus)

Abstract

Epigenetics is a quickly growing field encompassing mechanisms regulating gene expression that do not involve changes in the genotype. Epigenetics is of increasing relevance to neuroscience, with epigenetic mechanisms being implicated in brain development and neuronal differentiation, as well as in more dynamic processes related to cognition. Epigenetic regulation covers multiple levels of gene expression; from direct modifications of the DNA and histone tails, regulating the level of transcription, to interactions with messenger RNAs, regulating the level of translation. Importantly, epigenetic dysregulation currently garners much attention as a pivotal player in aging and age-related neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it may mediate interactions between genetic and environmental risk factors, or directly interact with disease-specific pathological factors. We review current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases. Additionally, we examine the current state of epigenetics-based therapeutic strategies for these diseases, which either aim to restore the epigenetic homeostasis or skew it to a favorable direction to counter disease pathology. Finally, methodological challenges of epigenetic investigations and future perspectives are discussed.

Original languageEnglish (US)
Pages (from-to)21-64
Number of pages44
JournalProgress in Neurobiology
Volume131
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Fingerprint

Epigenomics
Neurodegenerative Diseases
Histone Code
Gene Expression
Untranslated RNA
Chromatin Assembly and Disassembly
DNA
Huntington Disease
DNA Methylation
Neurosciences
Cognition
Parkinson Disease
Alzheimer Disease
Homeostasis
Genotype
Pathology
Messenger RNA
Brain

Keywords

  • Aging
  • Alzheimer's disease
  • Epigenetics
  • Huntington's disease
  • Neurodegeneration
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., ... Rutten, B. P. F. (2015). The epigenetics of aging and neurodegeneration. Progress in Neurobiology, 131, 21-64. https://doi.org/10.1016/j.pneurobio.2015.05.002

The epigenetics of aging and neurodegeneration. / Lardenoije, Roy; Iatrou, Artemis; Kenis, Gunter; Kompotis, Konstantinos; Steinbusch, Harry W.M.; Mastroeni, Diego; Coleman, Paul; Lemere, Cynthia A.; Hof, Patrick R.; van den Hove, Daniel L.A.; Rutten, Bart P.F.

In: Progress in Neurobiology, Vol. 131, 01.08.2015, p. 21-64.

Research output: Contribution to journalReview article

Lardenoije, R, Iatrou, A, Kenis, G, Kompotis, K, Steinbusch, HWM, Mastroeni, D, Coleman, P, Lemere, CA, Hof, PR, van den Hove, DLA & Rutten, BPF 2015, 'The epigenetics of aging and neurodegeneration', Progress in Neurobiology, vol. 131, pp. 21-64. https://doi.org/10.1016/j.pneurobio.2015.05.002
Lardenoije R, Iatrou A, Kenis G, Kompotis K, Steinbusch HWM, Mastroeni D et al. The epigenetics of aging and neurodegeneration. Progress in Neurobiology. 2015 Aug 1;131:21-64. https://doi.org/10.1016/j.pneurobio.2015.05.002
Lardenoije, Roy ; Iatrou, Artemis ; Kenis, Gunter ; Kompotis, Konstantinos ; Steinbusch, Harry W.M. ; Mastroeni, Diego ; Coleman, Paul ; Lemere, Cynthia A. ; Hof, Patrick R. ; van den Hove, Daniel L.A. ; Rutten, Bart P.F. / The epigenetics of aging and neurodegeneration. In: Progress in Neurobiology. 2015 ; Vol. 131. pp. 21-64.
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