The effects of females' susceptibility on the coexistence of multiple pathogen strains of sexually transmitted diseases

Carlos Castillo-Chavez, Wenzhang Huang, Jia Li

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We study the dynamics of sexually transmitted pathogens in a heterosexually active population, where females are divided into two different groups based on their susceptibility to two distinct pathogenic strains. It is assumed that a host cannot be invaded simultaneously by both disease agents and that when symptoms appear - a function of the pathogen, strain, virulence, and an individual's degree of susceptibility - then individuals are treated and/or recover. Heterogeneity in susceptibility to the acquisition of infection and/or in variability in the length of the infection period of the female subpopulations is incorporated. Pathogens' coexistence is highly unlikely on homogeneously mixing female and male populations with no heterogeneity among individuals of either gender. Variability in susceptibility in the female subpopulation makes coexistence possible albeit under a complex set of circumstances that must include differences in contact/mixing rates between the groups of females and the male population as well as differences in the lengths of their average periods of infectiousness for the three groups.

Original languageEnglish (US)
Pages (from-to)503-522
Number of pages20
JournalJournal of Mathematical Biology
Volume35
Issue number5
StatePublished - May 1997
Externally publishedYes

Fingerprint

sexually transmitted diseases
Pathogens
Sexually Transmitted Diseases
Coexistence
Susceptibility
pathogens
Infection
Population
infection
Contact
Virulence
Distinct
virulence
gender

Keywords

  • Coexistence
  • Pathogen strains
  • Sexually transmitted disease

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Mathematics (miscellaneous)

Cite this

The effects of females' susceptibility on the coexistence of multiple pathogen strains of sexually transmitted diseases. / Castillo-Chavez, Carlos; Huang, Wenzhang; Li, Jia.

In: Journal of Mathematical Biology, Vol. 35, No. 5, 05.1997, p. 503-522.

Research output: Contribution to journalArticle

@article{50cfff3ef98345458899ad262a813dc1,
title = "The effects of females' susceptibility on the coexistence of multiple pathogen strains of sexually transmitted diseases",
abstract = "We study the dynamics of sexually transmitted pathogens in a heterosexually active population, where females are divided into two different groups based on their susceptibility to two distinct pathogenic strains. It is assumed that a host cannot be invaded simultaneously by both disease agents and that when symptoms appear - a function of the pathogen, strain, virulence, and an individual's degree of susceptibility - then individuals are treated and/or recover. Heterogeneity in susceptibility to the acquisition of infection and/or in variability in the length of the infection period of the female subpopulations is incorporated. Pathogens' coexistence is highly unlikely on homogeneously mixing female and male populations with no heterogeneity among individuals of either gender. Variability in susceptibility in the female subpopulation makes coexistence possible albeit under a complex set of circumstances that must include differences in contact/mixing rates between the groups of females and the male population as well as differences in the lengths of their average periods of infectiousness for the three groups.",
keywords = "Coexistence, Pathogen strains, Sexually transmitted disease",
author = "Carlos Castillo-Chavez and Wenzhang Huang and Jia Li",
year = "1997",
month = "5",
language = "English (US)",
volume = "35",
pages = "503--522",
journal = "Journal of Mathematical Biology",
issn = "0303-6812",
publisher = "Springer Verlag",
number = "5",

}

TY - JOUR

T1 - The effects of females' susceptibility on the coexistence of multiple pathogen strains of sexually transmitted diseases

AU - Castillo-Chavez, Carlos

AU - Huang, Wenzhang

AU - Li, Jia

PY - 1997/5

Y1 - 1997/5

N2 - We study the dynamics of sexually transmitted pathogens in a heterosexually active population, where females are divided into two different groups based on their susceptibility to two distinct pathogenic strains. It is assumed that a host cannot be invaded simultaneously by both disease agents and that when symptoms appear - a function of the pathogen, strain, virulence, and an individual's degree of susceptibility - then individuals are treated and/or recover. Heterogeneity in susceptibility to the acquisition of infection and/or in variability in the length of the infection period of the female subpopulations is incorporated. Pathogens' coexistence is highly unlikely on homogeneously mixing female and male populations with no heterogeneity among individuals of either gender. Variability in susceptibility in the female subpopulation makes coexistence possible albeit under a complex set of circumstances that must include differences in contact/mixing rates between the groups of females and the male population as well as differences in the lengths of their average periods of infectiousness for the three groups.

AB - We study the dynamics of sexually transmitted pathogens in a heterosexually active population, where females are divided into two different groups based on their susceptibility to two distinct pathogenic strains. It is assumed that a host cannot be invaded simultaneously by both disease agents and that when symptoms appear - a function of the pathogen, strain, virulence, and an individual's degree of susceptibility - then individuals are treated and/or recover. Heterogeneity in susceptibility to the acquisition of infection and/or in variability in the length of the infection period of the female subpopulations is incorporated. Pathogens' coexistence is highly unlikely on homogeneously mixing female and male populations with no heterogeneity among individuals of either gender. Variability in susceptibility in the female subpopulation makes coexistence possible albeit under a complex set of circumstances that must include differences in contact/mixing rates between the groups of females and the male population as well as differences in the lengths of their average periods of infectiousness for the three groups.

KW - Coexistence

KW - Pathogen strains

KW - Sexually transmitted disease

UR - http://www.scopus.com/inward/record.url?scp=0031131720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031131720&partnerID=8YFLogxK

M3 - Article

VL - 35

SP - 503

EP - 522

JO - Journal of Mathematical Biology

JF - Journal of Mathematical Biology

SN - 0303-6812

IS - 5

ER -