The effects of changing atmospheric oxygen concentrations and background radiation levels on radiogenic DNA damage rates

P. Andrew Karam, Stephen A. Leslie, Ariel Anbar

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Both background radiation levels and atmospheric oxygen concentrations have changed dramatically over the history of life on earth. Because oxygen has a strong modifying influence on radiogenic mutation rates, these factors must be considered jointly to determine changes in radiogenic mutation rates over time. Using accepted models that describe how both of these parameters have changed through time, we find that radiogenic mutation rates in organisms have fluctuated between about 1.5 to 2.5 times current levels through most of the history of life. The results of this study have interesting implications that may impact our understanding of how modern organisms respond to radiation damage and of models that use molecular clocks to date species divergence times. It Is also possible that changing oxygen levels have served to buffer mutation rate changes that result from changes In background radiation levels over time.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalHealth Physics
Volume81
Issue number5
StatePublished - 2001
Externally publishedYes

Fingerprint

Background Radiation
background radiation
Mutation Rate
mutations
DNA Damage
mutation
deoxyribonucleic acid
Oxygen
damage
Radiation
DNA
oxygen
radiation
organisms
History
Radiation damage
histories
radiation damage
Molecular Models
Clocks

Keywords

  • Geology
  • Naturally occurring radionuclides
  • Radiation damage
  • Radiation, background

ASJC Scopus subject areas

  • Environmental Science (miscellaneous)
  • Health, Toxicology and Mutagenesis
  • Toxicology
  • Physics and Astronomy (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Environmental Chemistry
  • Environmental Science(all)

Cite this

The effects of changing atmospheric oxygen concentrations and background radiation levels on radiogenic DNA damage rates. / Karam, P. Andrew; Leslie, Stephen A.; Anbar, Ariel.

In: Health Physics, Vol. 81, No. 5, 2001, p. 545-553.

Research output: Contribution to journalArticle

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