The Effects of Amphetamine and Methamphetamine on Brain Activity-Related Immediate Early Gene Expression

Peter R. Kufahl; Elisabeth Moore; M. Foster Olive

doi:10.1016/B978-0-12-800212-4.00012-1

The Effects of Amphetamine and Methamphetamine on Brain Activity-Related Immediate Early Gene Expression

Peter R. Kufahl, Elisabeth Moore, M. Foster Olive

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Widespread abuse of amphetamine and methamphetamine remains a significant global health problem. Intervention efforts to reduce its use have focused on developing treatments that reverse or mitigate the neurological effects of these drugs that support addictive behaviors. Exposing rodents to amphetamine or methamphetamine and analyzing their brain tissue for genetic responses has proven to be a valuable tool for identifying the most relevant brain circuits for targeted treatment of drug abuse. Immediate early genes (IEGs), including transcription factors that coordinate stimulus-driven effects across a range of genes and signaling pathways, have been widely studied in efforts to map the neural responses to psychoactive drugs. This chapter provides an overview of studies that have examined the effects of amphetamine and methamphetamine treatment on expression patterns of the IEGs c-fos, arc, zif/268, and bdnf to characterize the neural effects of acute and chronic drug exposure.

Original language	English (US)
Title of host publication	Neuropathology of Drug Addictions and Substance Misuse Volume 2
Subtitle of host publication	Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects
Publisher	Elsevier
Pages	126-136
Number of pages	11
ISBN (Electronic)	9780128002124
ISBN (Print)	9780128003756
DOIs	https://doi.org/10.1016/B978-0-12-800212-4.00012-1
State	Published - Jan 1 2016
Externally published	Yes

Keywords

Amphetamine
Arc
Bdnf
C-Fos
Immediate early gene
Methamphetamine
Zif268

ASJC Scopus subject areas

General Psychology

Access to Document

10.1016/B978-0-12-800212-4.00012-1

Cite this

Kufahl, P. R., Moore, E., & Olive, M. F. (2016). The Effects of Amphetamine and Methamphetamine on Brain Activity-Related Immediate Early Gene Expression. In Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects (pp. 126-136). Elsevier. https://doi.org/10.1016/B978-0-12-800212-4.00012-1

The Effects of Amphetamine and Methamphetamine on Brain Activity-Related Immediate Early Gene Expression. / Kufahl, Peter R.; Moore, Elisabeth; Olive, M. Foster.
Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects. Elsevier, 2016. p. 126-136.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Kufahl, PR, Moore, E & Olive, MF 2016, The Effects of Amphetamine and Methamphetamine on Brain Activity-Related Immediate Early Gene Expression. in Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects. Elsevier, pp. 126-136. https://doi.org/10.1016/B978-0-12-800212-4.00012-1

Kufahl PR, Moore E, Olive MF. The Effects of Amphetamine and Methamphetamine on Brain Activity-Related Immediate Early Gene Expression. In Neuropathology of Drug Addictions and Substance Misuse Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects. Elsevier. 2016. p. 126-136 doi: 10.1016/B978-0-12-800212-4.00012-1

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The Effects of Amphetamine and Methamphetamine on Brain Activity-Related Immediate Early Gene Expression

Abstract

Keywords

ASJC Scopus subject areas

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