The Effects of Amphetamine and Methamphetamine on Brain Activity-Related Immediate Early Gene Expression

Peter R. Kufahl, Elisabeth Moore, M. Foster Olive

Research output: Chapter in Book/Report/Conference proceedingChapter


Widespread abuse of amphetamine and methamphetamine remains a significant global health problem. Intervention efforts to reduce its use have focused on developing treatments that reverse or mitigate the neurological effects of these drugs that support addictive behaviors. Exposing rodents to amphetamine or methamphetamine and analyzing their brain tissue for genetic responses has proven to be a valuable tool for identifying the most relevant brain circuits for targeted treatment of drug abuse. Immediate early genes (IEGs), including transcription factors that coordinate stimulus-driven effects across a range of genes and signaling pathways, have been widely studied in efforts to map the neural responses to psychoactive drugs. This chapter provides an overview of studies that have examined the effects of amphetamine and methamphetamine treatment on expression patterns of the IEGs c-fos, arc, zif/268, and bdnf to characterize the neural effects of acute and chronic drug exposure.

Original languageEnglish (US)
Title of host publicationNeuropathology of Drug Addictions and Substance Misuse Volume 2
Subtitle of host publicationStimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects
Number of pages11
ISBN (Electronic)9780128002124
ISBN (Print)9780128003756
StatePublished - Jan 1 2016
Externally publishedYes


  • Amphetamine
  • Arc
  • Bdnf
  • C-Fos
  • Immediate early gene
  • Methamphetamine
  • Zif268

ASJC Scopus subject areas

  • Psychology(all)


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