The Effect of Renal Insufficiency on Mycophenolic Acid Protein Binding

Bruce Kaplan, H. U. Meier-Kriesche, Gary Friedman, Shamkant Mulgaonkar, Scott Gruber, Magda Korecka, Kenneth L. Brayman, Leslie M. Shaw

Research output: Contribution to journalArticle

129 Citations (Scopus)

Abstract

Mycophenolate mofetil (MMF) is commonly used in solid organ transplant recipients. MMF is converted to mycophenolic acid (MPA) upon reaching the systemic circulation. Many acidic drugs have altered protein binding in renal failure, and it is possible that MPA protein binding may be decreased. The authors studied 23 renal transplant recipients: 8 transplant patients (7 kidney, 1 kidney/pancreas) with chronic renal insufficiency (CRI) and 15 renal transplant patients with preserved renal function. Plasma was obtained for kinetic profiles of total MPA, free MPA, and its glucuronide metabolite (MPAG). Plasma was obtained from 10 hemodialysis patients and 8 healthy control volunteers to assess in vitro differences in MPA protein binding. Average free fraction of MPA in patients with chronic renal insufficiency was more than double that of patients with normal renal function (5.8±2.7 vs. 2.5±0.4, p<0.01). Free MPAAUC was almost doubled in the patients with chronic renal insufficiency versus controls (2.04±.08 vs. 1.03±0.6, p <0.01). MPA protein binding is decreased, and free MPA concentrations are increased in patients with chronic renal failure.

Original languageEnglish (US)
Pages (from-to)715-720
Number of pages6
JournalJournal of Clinical Pharmacology
Volume39
Issue number7
DOIs
StatePublished - 1999
Externally publishedYes

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Mycophenolic Acid
Protein Binding
Renal Insufficiency
Kidney
Chronic Renal Insufficiency
Transplants
Chronic Kidney Failure
Renal Dialysis
Pancreas
Healthy Volunteers

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kaplan, B., Meier-Kriesche, H. U., Friedman, G., Mulgaonkar, S., Gruber, S., Korecka, M., ... Shaw, L. M. (1999). The Effect of Renal Insufficiency on Mycophenolic Acid Protein Binding. Journal of Clinical Pharmacology, 39(7), 715-720. https://doi.org/10.1177/00912709922008353

The Effect of Renal Insufficiency on Mycophenolic Acid Protein Binding. / Kaplan, Bruce; Meier-Kriesche, H. U.; Friedman, Gary; Mulgaonkar, Shamkant; Gruber, Scott; Korecka, Magda; Brayman, Kenneth L.; Shaw, Leslie M.

In: Journal of Clinical Pharmacology, Vol. 39, No. 7, 1999, p. 715-720.

Research output: Contribution to journalArticle

Kaplan, B, Meier-Kriesche, HU, Friedman, G, Mulgaonkar, S, Gruber, S, Korecka, M, Brayman, KL & Shaw, LM 1999, 'The Effect of Renal Insufficiency on Mycophenolic Acid Protein Binding', Journal of Clinical Pharmacology, vol. 39, no. 7, pp. 715-720. https://doi.org/10.1177/00912709922008353
Kaplan B, Meier-Kriesche HU, Friedman G, Mulgaonkar S, Gruber S, Korecka M et al. The Effect of Renal Insufficiency on Mycophenolic Acid Protein Binding. Journal of Clinical Pharmacology. 1999;39(7):715-720. https://doi.org/10.1177/00912709922008353
Kaplan, Bruce ; Meier-Kriesche, H. U. ; Friedman, Gary ; Mulgaonkar, Shamkant ; Gruber, Scott ; Korecka, Magda ; Brayman, Kenneth L. ; Shaw, Leslie M. / The Effect of Renal Insufficiency on Mycophenolic Acid Protein Binding. In: Journal of Clinical Pharmacology. 1999 ; Vol. 39, No. 7. pp. 715-720.
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