The effect of rabbit anti-mouse brain-associated θ serum on the immunologic responsiveness of AKR mice

Anna Barker, Melvin S. Rheins, Ronald L St Pierre

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Rabbit anti-C3H mouse brain-associated antiserum (BA-θ) was tested for its effect on the immunologic responsiveness of preleukemic and leukemic AKR mice to sheep erythrocytes. This BA-θ antiserum was cytotoxic in vitro for both C3H and for AKR thymocytes, and was immunosuppressive in vivo. Greater immunosuppression was effected by the antiserum in preleukemic AKR mice than in leukemic animals. Control rabbit serum also was cytotoxic in vitro and immunosuppressive in vivo, but this activity was removed by absorption with homologous erythrocytes and liver tissue, and with agarose. Conversely, absorption of the rabbit anti-BA-θ serum had no effect on either the in vitro cytotoxic activity, or on the in vivo immunosuppression.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalCellular Immunology
Volume7
Issue number1
DOIs
StatePublished - 1973
Externally publishedYes

Fingerprint

Inbred AKR Mouse
Immune Sera
Immunosuppressive Agents
Rabbits
Immunosuppression
Brain
Erythrocytes
Serum
Inbred C3H Mouse
Thymocytes
Sepharose
Sheep
Liver
In Vitro Techniques

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

The effect of rabbit anti-mouse brain-associated θ serum on the immunologic responsiveness of AKR mice. / Barker, Anna; Rheins, Melvin S.; Pierre, Ronald L St.

In: Cellular Immunology, Vol. 7, No. 1, 1973, p. 85-91.

Research output: Contribution to journalArticle

Barker, Anna ; Rheins, Melvin S. ; Pierre, Ronald L St. / The effect of rabbit anti-mouse brain-associated θ serum on the immunologic responsiveness of AKR mice. In: Cellular Immunology. 1973 ; Vol. 7, No. 1. pp. 85-91.
@article{a9968f84938d4923b8239c11a8e94018,
title = "The effect of rabbit anti-mouse brain-associated θ serum on the immunologic responsiveness of AKR mice",
abstract = "Rabbit anti-C3H mouse brain-associated antiserum (BA-θ) was tested for its effect on the immunologic responsiveness of preleukemic and leukemic AKR mice to sheep erythrocytes. This BA-θ antiserum was cytotoxic in vitro for both C3H and for AKR thymocytes, and was immunosuppressive in vivo. Greater immunosuppression was effected by the antiserum in preleukemic AKR mice than in leukemic animals. Control rabbit serum also was cytotoxic in vitro and immunosuppressive in vivo, but this activity was removed by absorption with homologous erythrocytes and liver tissue, and with agarose. Conversely, absorption of the rabbit anti-BA-θ serum had no effect on either the in vitro cytotoxic activity, or on the in vivo immunosuppression.",
author = "Anna Barker and Rheins, {Melvin S.} and Pierre, {Ronald L St}",
year = "1973",
doi = "10.1016/0008-8749(73)90184-6",
language = "English (US)",
volume = "7",
pages = "85--91",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The effect of rabbit anti-mouse brain-associated θ serum on the immunologic responsiveness of AKR mice

AU - Barker, Anna

AU - Rheins, Melvin S.

AU - Pierre, Ronald L St

PY - 1973

Y1 - 1973

N2 - Rabbit anti-C3H mouse brain-associated antiserum (BA-θ) was tested for its effect on the immunologic responsiveness of preleukemic and leukemic AKR mice to sheep erythrocytes. This BA-θ antiserum was cytotoxic in vitro for both C3H and for AKR thymocytes, and was immunosuppressive in vivo. Greater immunosuppression was effected by the antiserum in preleukemic AKR mice than in leukemic animals. Control rabbit serum also was cytotoxic in vitro and immunosuppressive in vivo, but this activity was removed by absorption with homologous erythrocytes and liver tissue, and with agarose. Conversely, absorption of the rabbit anti-BA-θ serum had no effect on either the in vitro cytotoxic activity, or on the in vivo immunosuppression.

AB - Rabbit anti-C3H mouse brain-associated antiserum (BA-θ) was tested for its effect on the immunologic responsiveness of preleukemic and leukemic AKR mice to sheep erythrocytes. This BA-θ antiserum was cytotoxic in vitro for both C3H and for AKR thymocytes, and was immunosuppressive in vivo. Greater immunosuppression was effected by the antiserum in preleukemic AKR mice than in leukemic animals. Control rabbit serum also was cytotoxic in vitro and immunosuppressive in vivo, but this activity was removed by absorption with homologous erythrocytes and liver tissue, and with agarose. Conversely, absorption of the rabbit anti-BA-θ serum had no effect on either the in vitro cytotoxic activity, or on the in vivo immunosuppression.

UR - http://www.scopus.com/inward/record.url?scp=0015611573&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015611573&partnerID=8YFLogxK

U2 - 10.1016/0008-8749(73)90184-6

DO - 10.1016/0008-8749(73)90184-6

M3 - Article

VL - 7

SP - 85

EP - 91

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -