The effect of oxygen on biochemical networks and the evolution of complex life

Jason Raymond, Daniel Segrè

Research output: Contribution to journalArticle

286 Citations (Scopus)

Abstract

The evolution of oxygenic photosynthesis and ensuing oxygenation of Earth's atmosphere represent a major transition in the history of life. Although many organisms retreated to anoxic environments, others, evolved to use oxygen as a high-potential redox couple while concomitantly mitigating its toxicity. To understand the changes in biochemistry and enzymology that accompanied adaptation to O2, we integrated network analysis with information on enzyme evolution to infer how oxygen availability changed the architecture of metabolic networks. Our analysis revealed the existence of four discrete groups of networks of increasing complexity, with transitions between groups being contingent on the presence of key metabolites, including molecular oxygen, which was required for transition into the largest networks.

Original languageEnglish (US)
Pages (from-to)1764-1767
Number of pages4
JournalScience
Volume311
Issue number5768
DOIs
StatePublished - Mar 24 2006
Externally publishedYes

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Oxygen
Photosynthesis
Metabolic Networks and Pathways
Atmosphere
Biochemistry
Oxidation-Reduction
History
Enzymes

ASJC Scopus subject areas

  • General

Cite this

The effect of oxygen on biochemical networks and the evolution of complex life. / Raymond, Jason; Segrè, Daniel.

In: Science, Vol. 311, No. 5768, 24.03.2006, p. 1764-1767.

Research output: Contribution to journalArticle

Raymond, Jason ; Segrè, Daniel. / The effect of oxygen on biochemical networks and the evolution of complex life. In: Science. 2006 ; Vol. 311, No. 5768. pp. 1764-1767.
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