The effect of cimetidine on antibody synthesis in vitro and in vivo

A. M. Badger; A. E. Brown; G. Poste

The effect of cimetidine on antibody synthesis in vitro and in vivo

A. M. Badger, A. E. Brown, G. Poste

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of the H₂-receptor antagonist cimetidine on the antibody response of murine spleen cells to sheep red blood cells (SRBC) has been examined in vitro and in vivo. Studies failed to demonstrate any detectable effect of the drug in vitro over a wide range of concentrations (10^-12 to 10^-4 M). In vivo, cimetidine stimulated IgM but not IgG responses. This effect was more marked on the secondary rather than the primary response. Low doses of cimetidine (0.5-10 mg/kg) enhanced the secondary IgM response better than high concentrations (50-100 mg/kg).

Original language	English (US)
Pages (from-to)	151-155
Number of pages	5
Journal	Immunology
Volume	48
Issue number	1
State	Published - Jan 1 1983
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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N2 - The effects of the H2-receptor antagonist cimetidine on the antibody response of murine spleen cells to sheep red blood cells (SRBC) has been examined in vitro and in vivo. Studies failed to demonstrate any detectable effect of the drug in vitro over a wide range of concentrations (10-12 to 10-4 M). In vivo, cimetidine stimulated IgM but not IgG responses. This effect was more marked on the secondary rather than the primary response. Low doses of cimetidine (0.5-10 mg/kg) enhanced the secondary IgM response better than high concentrations (50-100 mg/kg).

AB - The effects of the H2-receptor antagonist cimetidine on the antibody response of murine spleen cells to sheep red blood cells (SRBC) has been examined in vitro and in vivo. Studies failed to demonstrate any detectable effect of the drug in vitro over a wide range of concentrations (10-12 to 10-4 M). In vivo, cimetidine stimulated IgM but not IgG responses. This effect was more marked on the secondary rather than the primary response. Low doses of cimetidine (0.5-10 mg/kg) enhanced the secondary IgM response better than high concentrations (50-100 mg/kg).

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JO - Immunology

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The effect of cimetidine on antibody synthesis in vitro and in vivo

Abstract

ASJC Scopus subject areas

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