The effect of body mass index on long-term renal allograft survival

Herwig Ulf Meier-Kriesche, Mahesh Vaghela, Rama Thambuganipalle, Gary Friedman, Martin Jacobs, Bruce Kaplan

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Background. A number of factors have been implicated in decreasing long- term renal graft survival. Factors such as living versus cadaveric donor status, acute rejection, and HLA matching have been studied in detail. Mild obesity defined as a body mass index (BMI) of >25 has been found to have a deleterious effect on a number of physiologic processes. We studied the effect of a BMI >25 on long-term renal transplantation outcome. Methods. A total of 405 patients who underwent transplantation at Saint Barnabas Medical Center from 1990 to 1997 were evaluated. All known variables impacting on long-term graft function were collected. Multivariate analysis utilizing the Cox-proportional hazard model and Kaplan-Meier actuarial survival were applied to these risk factors. Results. BMI >25 was isolated as an independent risk factor for both decreased graft survival and patient survival (relative risk 2.0 for each). Cadaveric donor status, acute rejection, and use of azathioprine versus mycophenolate mofetil were the only other significant risk factors. Conclusions. Mild obesity before transplantation has a negative impact on long-term renal graft and patient survival.

Original languageEnglish (US)
Pages (from-to)1294-1297
Number of pages4
JournalTransplantation
Volume68
Issue number9
StatePublished - Nov 15 1999
Externally publishedYes

Fingerprint

Graft Survival
Allografts
Body Mass Index
Kidney
Obesity
Transplantation
Tissue Donors
Mycophenolic Acid
Survival
Azathioprine
Proportional Hazards Models
Kidney Transplantation
Multivariate Analysis
Transplants

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Meier-Kriesche, H. U., Vaghela, M., Thambuganipalle, R., Friedman, G., Jacobs, M., & Kaplan, B. (1999). The effect of body mass index on long-term renal allograft survival. Transplantation, 68(9), 1294-1297.

The effect of body mass index on long-term renal allograft survival. / Meier-Kriesche, Herwig Ulf; Vaghela, Mahesh; Thambuganipalle, Rama; Friedman, Gary; Jacobs, Martin; Kaplan, Bruce.

In: Transplantation, Vol. 68, No. 9, 15.11.1999, p. 1294-1297.

Research output: Contribution to journalArticle

Meier-Kriesche, HU, Vaghela, M, Thambuganipalle, R, Friedman, G, Jacobs, M & Kaplan, B 1999, 'The effect of body mass index on long-term renal allograft survival', Transplantation, vol. 68, no. 9, pp. 1294-1297.
Meier-Kriesche HU, Vaghela M, Thambuganipalle R, Friedman G, Jacobs M, Kaplan B. The effect of body mass index on long-term renal allograft survival. Transplantation. 1999 Nov 15;68(9):1294-1297.
Meier-Kriesche, Herwig Ulf ; Vaghela, Mahesh ; Thambuganipalle, Rama ; Friedman, Gary ; Jacobs, Martin ; Kaplan, Bruce. / The effect of body mass index on long-term renal allograft survival. In: Transplantation. 1999 ; Vol. 68, No. 9. pp. 1294-1297.
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