TY - JOUR
T1 - The effect of body mass index on long-term renal allograft survival
AU - Meier-Kriesche, Herwig Ulf
AU - Vaghela, Mahesh
AU - Thambuganipalle, Rama
AU - Friedman, Gary
AU - Jacobs, Martin
AU - Kaplan, Bruce
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1999/11/15
Y1 - 1999/11/15
N2 - Background. A number of factors have been implicated in decreasing long- term renal graft survival. Factors such as living versus cadaveric donor status, acute rejection, and HLA matching have been studied in detail. Mild obesity defined as a body mass index (BMI) of >25 has been found to have a deleterious effect on a number of physiologic processes. We studied the effect of a BMI >25 on long-term renal transplantation outcome. Methods. A total of 405 patients who underwent transplantation at Saint Barnabas Medical Center from 1990 to 1997 were evaluated. All known variables impacting on long-term graft function were collected. Multivariate analysis utilizing the Cox-proportional hazard model and Kaplan-Meier actuarial survival were applied to these risk factors. Results. BMI >25 was isolated as an independent risk factor for both decreased graft survival and patient survival (relative risk 2.0 for each). Cadaveric donor status, acute rejection, and use of azathioprine versus mycophenolate mofetil were the only other significant risk factors. Conclusions. Mild obesity before transplantation has a negative impact on long-term renal graft and patient survival.
AB - Background. A number of factors have been implicated in decreasing long- term renal graft survival. Factors such as living versus cadaveric donor status, acute rejection, and HLA matching have been studied in detail. Mild obesity defined as a body mass index (BMI) of >25 has been found to have a deleterious effect on a number of physiologic processes. We studied the effect of a BMI >25 on long-term renal transplantation outcome. Methods. A total of 405 patients who underwent transplantation at Saint Barnabas Medical Center from 1990 to 1997 were evaluated. All known variables impacting on long-term graft function were collected. Multivariate analysis utilizing the Cox-proportional hazard model and Kaplan-Meier actuarial survival were applied to these risk factors. Results. BMI >25 was isolated as an independent risk factor for both decreased graft survival and patient survival (relative risk 2.0 for each). Cadaveric donor status, acute rejection, and use of azathioprine versus mycophenolate mofetil were the only other significant risk factors. Conclusions. Mild obesity before transplantation has a negative impact on long-term renal graft and patient survival.
UR - http://www.scopus.com/inward/record.url?scp=0033571556&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033571556&partnerID=8YFLogxK
U2 - 10.1097/00007890-199911150-00013
DO - 10.1097/00007890-199911150-00013
M3 - Article
C2 - 10573066
AN - SCOPUS:0033571556
SN - 0041-1337
VL - 68
SP - 1294
EP - 1297
JO - Transplantation
JF - Transplantation
IS - 9
ER -