The Dolastatins. 21. Synthesis, X-ray Crystal Structure, and Molecular Modeling of (6R)-Isodolastatin 10

George Pettit; Jayaram K. Srirangam; Delbert L. Herald; Ernest Hamel

doi:10.1021/jo00100a001

The Dolastatins. 21. Synthesis, X-ray Crystal Structure, and Molecular Modeling of (6R)-Isodolastatin 10

George Pettit, Jayaram K. Srirangam, Delbert L. Herald, Ernest Hamel

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A practical synthesis of (6R)-isodolastatin 10 (1b) was devised, the X-ray crystal structure was determined, and this chiral isomer was found to have antineoplastic activity comparable to dolastatin 10 (1a).

Original language	English (US)
Pages (from-to)	6127-6130
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	59
Issue number	21
DOIs	https://doi.org/10.1021/jo00100a001
State	Published - Oct 1 1994

ASJC Scopus subject areas

Organic Chemistry

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title = "The Dolastatins. 21. Synthesis, X-ray Crystal Structure, and Molecular Modeling of (6R)-Isodolastatin 10",

abstract = "A practical synthesis of (6R)-isodolastatin 10 (1b) was devised, the X-ray crystal structure was determined, and this chiral isomer was found to have antineoplastic activity comparable to dolastatin 10 (1a).",

author = "George Pettit and Srirangam, {Jayaram K.} and Herald, {Delbert L.} and Ernest Hamel",

year = "1994",

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day = "1",

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language = "English (US)",

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AU - Pettit, George

AU - Srirangam, Jayaram K.

AU - Herald, Delbert L.

AU - Hamel, Ernest

PY - 1994/10/1

Y1 - 1994/10/1

N2 - A practical synthesis of (6R)-isodolastatin 10 (1b) was devised, the X-ray crystal structure was determined, and this chiral isomer was found to have antineoplastic activity comparable to dolastatin 10 (1a).

AB - A practical synthesis of (6R)-isodolastatin 10 (1b) was devised, the X-ray crystal structure was determined, and this chiral isomer was found to have antineoplastic activity comparable to dolastatin 10 (1a).

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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The Dolastatins. 21. Synthesis, X-ray Crystal Structure, and Molecular Modeling of (6R)-Isodolastatin 10

Abstract

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