The Dolastatins. 21. Synthesis, X-ray Crystal Structure, and Molecular Modeling of (6R)-Isodolastatin 10

George Pettit, Jayaram K. Srirangam, Delbert L. Herald, Ernest Hamel

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A practical synthesis of (6R)-isodolastatin 10 (1b) was devised, the X-ray crystal structure was determined, and this chiral isomer was found to have antineoplastic activity comparable to dolastatin 10 (1a).

Original languageEnglish (US)
Pages (from-to)6127-6130
Number of pages4
JournalJournal of Organic Chemistry
Volume59
Issue number21
DOIs
StatePublished - Oct 1 1994

ASJC Scopus subject areas

  • Organic Chemistry

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