The development of quantitative AOPs

Irvin R. Schultz, Karen Watanabe-Sailor

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    A quantitative adverse outcome pathway (qAOP) is a mathematical/computational model that represents the dynamic processes linking a molecular initiating event with an adverse outcome. A unique feature that distinguishes a qAOP from other biologically based mathematical models is the prediction of key events that are part of the qualitative adverse outcome pathway and are measurable experimentally. This chapter reviews the evolution of qAOPs, describes methods to develop qAOPs, and provides two case study examples focused on reproduction in fish.

    Original languageEnglish (US)
    Title of host publicationA Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment
    PublisherSpringer International Publishing
    Pages263-280
    Number of pages18
    ISBN (Electronic)9783319660844
    ISBN (Print)9783319660820
    DOIs
    StatePublished - Feb 24 2018

    Fingerprint

    dynamic models
    Fish
    Theoretical Models
    mathematical models
    Mathematical models
    case studies
    prediction
    fish
    Reproduction
    Fishes
    methodology

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Medicine(all)
    • Pharmacology, Toxicology and Pharmaceutics(all)

    Cite this

    Schultz, I. R., & Watanabe-Sailor, K. (2018). The development of quantitative AOPs. In A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment (pp. 263-280). Springer International Publishing. https://doi.org/10.1007/978-3-319-66084-4_13

    The development of quantitative AOPs. / Schultz, Irvin R.; Watanabe-Sailor, Karen.

    A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Springer International Publishing, 2018. p. 263-280.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Schultz, IR & Watanabe-Sailor, K 2018, The development of quantitative AOPs. in A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Springer International Publishing, pp. 263-280. https://doi.org/10.1007/978-3-319-66084-4_13
    Schultz IR, Watanabe-Sailor K. The development of quantitative AOPs. In A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Springer International Publishing. 2018. p. 263-280 https://doi.org/10.1007/978-3-319-66084-4_13
    Schultz, Irvin R. ; Watanabe-Sailor, Karen. / The development of quantitative AOPs. A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment. Springer International Publishing, 2018. pp. 263-280
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