TY - JOUR
T1 - The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk
T2 - The Gray Matters randomized trial
AU - Norton, Maria C.
AU - Clark, Christine J.
AU - Tschanz, Jo Ann T.
AU - Hartin, Phillip
AU - Fauth, Elizabeth B.
AU - Gast, Julie A.
AU - Dorsch, Travis E.
AU - Wengreen, Heidi
AU - Nugent, Chris
AU - Robinson, W. David
AU - Lefevre, Michael
AU - McClean, Sally
AU - Cleland, Ian
AU - Schaefer, Sydney Y.
AU - Aguilar, Sheryl
N1 - Funding Information:
This research was supported by the Office of the Vice President for Research and Graduate Studies, Utah State University, the Emma Eccles Jones College of Education and Human Services, Utah State University, Nike Corporation, the Intermountain Logan Regional Hospital Foundation, the Department of Education and Learning Northern Ireland, and the Computer Science Research Institute at the University of Ulster. The authors want to express appreciation and extend thanks to the following individuals and organizations in the Cache County, Utah area who assisted with the development and delivery of intervention components: Rich Gordon, Roxane Pfister, Martha Cannon, Craig Jessop, J.R. Dennison, Lesther Pappa, Stephanie Behrens, Elizabeth Nix, Dave Wallace, the Sports Academy and Racquet Club, Cache Valley Strength & Conditioning, Kubex Fitness, the City of Logan Aquatic Center, the Whittier Community Center, and Natural Philosophy Yoga Studio. Finally, the authors are grateful to have had the enthusiastic involvement and hard work of the team of 51 student research interns and the support and participation of the 146 community residents who were subjects in this pilot study.
Publisher Copyright:
© 2015 The Authors.
PY - 2015/10/14
Y1 - 2015/10/14
N2 - Introduction Most Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study. Methods This proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys. Results Midway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change. Discussion Participants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.
AB - Introduction Most Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study. Methods This proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys. Results Midway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change. Discussion Participants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.
KW - Lifestyle behavioral intervention
KW - Middle age
KW - Multidomain
KW - Randomized controlled trial
KW - Technology
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U2 - 10.1016/j.trci.2015.05.001
DO - 10.1016/j.trci.2015.05.001
M3 - Article
AN - SCOPUS:84944049002
SN - 2352-8737
VL - 1
SP - 53
EP - 62
JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions
JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions
IS - 1
ER -