The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial

Maria C. Norton, Christine J. Clark, Jo Ann T. Tschanz, Phillip Hartin, Elizabeth B. Fauth, Julie A. Gast, Travis E. Dorsch, Heidi Wengreen, Chris Nugent, W. David Robinson, Michael Lefevre, Sally McClean, Ian Cleland, Sydney Y. Schaefer, Sheryl Aguilar

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Introduction Most Alzheimer's disease (AD) prevention studies focus on older adults or persons with existing cognitive impairment. This study describes the design and progress of a novel pilot intervention, the Gray Matters study. Methods This proof-of-concept randomized controlled trial tests an evidence-based multidomain lifestyle intervention in 146 persons aged 40 to 64 years, in northern Utah. Data collectors were blinded to participants' randomization to treatment (n = 104) or control (n = 42). Intervention targeted physical activity, food choices, social engagement, cognitive simulation, sleep quality, and stress management, and uses a custom smartphone application, activity monitor, and educational materials. Secondary outcomes include biomarkers, body mass index, cognitive testing, and psychological surveys. Results Midway through the study, achievements include a 98.7% retention rate, a 96% rate of compliance with app data entry, and positive trends in behavioral change. Discussion Participants were empowered, learning that lifestyle might impact AD risk, exhibiting positive behavioral changes thus far.

Original languageEnglish (US)
Pages (from-to)53-62
Number of pages10
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume1
Issue number1
DOIs
StatePublished - Oct 14 2015

Keywords

  • Lifestyle behavioral intervention
  • Middle age
  • Multidomain
  • Randomized controlled trial
  • Technology

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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    Norton, M. C., Clark, C. J., Tschanz, J. A. T., Hartin, P., Fauth, E. B., Gast, J. A., Dorsch, T. E., Wengreen, H., Nugent, C., Robinson, W. D., Lefevre, M., McClean, S., Cleland, I., Schaefer, S. Y., & Aguilar, S. (2015). The design and progress of a multidomain lifestyle intervention to improve brain health in middle-aged persons to reduce later Alzheimer's disease risk: The Gray Matters randomized trial. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 1(1), 53-62. https://doi.org/10.1016/j.trci.2015.05.001