TY - JOUR
T1 - The demographic history of african drosophila melanogaster
AU - Kapopoulou, Adamandia
AU - Pfeifer, Susanne
AU - Jensen, Jeffrey
AU - Laurent, Stefan
N1 - Funding Information:
We thank Roman Arguello for helpful discussions and for providing the coordinates of short introns and 4-fold degenerate coding sites for the neutral set of loci. We also thank Athanasios Kousathanas and Anna-Sapfo Malaspinas for useful feedback. This work was supported by grants from the Swiss National Science Foundation and the European Research Council to J.D.J.
Publisher Copyright:
© The Author(s) 2018.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - As one of the most commonly utilized organisms in the study of local adaptation, an accurate characterization of the demographic history of Drosophilamelanogaster remains as an important research question. This owes both to the inherent interest in characterizing the population history of this model organism, as well as to the well-established importance of an accurate null demographic model for increasing power and decreasing false positive rates in genomic scans for positive selection. Although considerable attention has been afforded to this issue in non-African populations, less is known about the demographic history of African populations, including from the ancestral range of the species. While qualitative predictions and hypotheses have previously been forwarded, we here present a quantitative model fitting of the population history characterizing both the ancestral Zambian population range as well as the subsequently colonized west African populations, which themselves served as the source of multiple non-African colonization events. We here report the split time of theWest African population at 72 kya, a date corresponding to human migration into this region as well as a period of climatic changes in the African continent. Furthermore, we have estimated population sizes at this split time. These parameter estimates thus represent an important null model for future investigations in to African and non-African D. melanogaster populations alike.
AB - As one of the most commonly utilized organisms in the study of local adaptation, an accurate characterization of the demographic history of Drosophilamelanogaster remains as an important research question. This owes both to the inherent interest in characterizing the population history of this model organism, as well as to the well-established importance of an accurate null demographic model for increasing power and decreasing false positive rates in genomic scans for positive selection. Although considerable attention has been afforded to this issue in non-African populations, less is known about the demographic history of African populations, including from the ancestral range of the species. While qualitative predictions and hypotheses have previously been forwarded, we here present a quantitative model fitting of the population history characterizing both the ancestral Zambian population range as well as the subsequently colonized west African populations, which themselves served as the source of multiple non-African colonization events. We here report the split time of theWest African population at 72 kya, a date corresponding to human migration into this region as well as a period of climatic changes in the African continent. Furthermore, we have estimated population sizes at this split time. These parameter estimates thus represent an important null model for future investigations in to African and non-African D. melanogaster populations alike.
KW - Demographic inference
KW - Drosophila melanogaster
KW - Inversion polymorphisms
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U2 - 10.1093/gbe/evy185
DO - 10.1093/gbe/evy185
M3 - Review article
C2 - 30169784
AN - SCOPUS:85055701231
SN - 1759-6653
VL - 10
SP - 2338
EP - 2342
JO - Genome biology and evolution
JF - Genome biology and evolution
IS - 9
ER -