The cyclooxygenase-2 pathway as a target for treatment or prevention of cancer

Colin G. Crosby, Raymond N. DuBois

    Research output: Contribution to journalReview articlepeer-review

    35 Scopus citations

    Abstract

    Cyclooxygenase (COX)-2, an inducible enzyme involved in prostaglandin biosynthesis, has attracted considerable attention recently, due to its role in human cancer biology. Several studies have correlated an increase in the expression of COX-2 with a poor clinical outcome, while epidemiological studies demonstrate a reduced risk of cancer mortality in persons with long-term, chronic ingestion of non-steroidal anti-inflammatory drugs (NSAIDs). Originally, these observations were made in patients with colorectal cancer, and subsequent studies suggest a protective role of NSAIDs in other human cancers as well. With the development of COX-2 specific inhibitors, numerous laboratory and clinical studies are underway to help understand the role of COX-2 in cancer and the potential use of COX-2 selective inhibitors for cancer treatment or prevention. This review focuses on the physiological function of COX, and the clinical rationale for evaluating COX-2 selective inhibitors for use in oncology.

    Original languageEnglish (US)
    Pages (from-to)1-7
    Number of pages7
    JournalExpert Opinion on Emerging Drugs
    Volume8
    Issue number1
    DOIs
    StatePublished - May 2003

    Keywords

    • Cancer prevention
    • Celecoxib
    • Cyclooxygenase
    • Non-steroidal anti-inflammatory drugs
    • Rofecoxib

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

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