The crosstalk of PTGS2 and EGF signaling pathways in colorectal cancer

Dingzhi Wang; Dianren Xia; Raymond N. DuBois

doi:10.3390/cancers3043894

The crosstalk of PTGS2 and EGF signaling pathways in colorectal cancer

Dingzhi Wang, Dianren Xia, Raymond N. DuBois

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.

Original language	English (US)
Pages (from-to)	3894-3908
Number of pages	15
Journal	Cancers
Volume	3
Issue number	4
DOIs	https://doi.org/10.3390/cancers3043894
State	Published - Dec 2011

Keywords

COX-2
Colorectal cancer
EGFR
PTGS2

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers3043894

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title = "The crosstalk of PTGS2 and EGF signaling pathways in colorectal cancer",

abstract = "Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.",

keywords = "COX-2, Colorectal cancer, EGFR, PTGS2",

author = "Dingzhi Wang and Dianren Xia and DuBois, {Raymond N.}",

year = "2011",

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AU - Xia, Dianren

AU - DuBois, Raymond N.

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N2 - Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.

AB - Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.

KW - COX-2

KW - Colorectal cancer

KW - EGFR

KW - PTGS2

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The crosstalk of PTGS2 and EGF signaling pathways in colorectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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