The crosstalk of PTGS2 and EGF signaling pathways in colorectal cancer

Dingzhi Wang, Dianren Xia, Raymond N. DuBois

    Research output: Contribution to journalReview articlepeer-review

    32 Scopus citations

    Abstract

    Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.

    Original languageEnglish (US)
    Pages (from-to)3894-3908
    Number of pages15
    JournalCancers
    Volume3
    Issue number4
    DOIs
    StatePublished - Dec 2011

    Keywords

    • COX-2
    • Colorectal cancer
    • EGFR
    • PTGS2

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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