The CpxR/CpxA Two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia coli resistance to a model antimicrobial peptide

Natasha Weatherspoon-Griffin, Dezhi Yang, Wei Kong, Zichun Hua, Yixin Shi

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Background: The CpxR/CpxA system facilitates E. coli resistance to antimicrobial peptides. However, many CpxR-dependent mechanisms remain elusive.

Results: The CpxR/CpxA system activates mar transcription, subsequently facilitating E. coli resistance to protamine via tripartite multidrug transporters.

Conclusion: A CpxR/CpxA-dependent regulatory cascade controls MarRA for CAMP resistance in response to aromatic metabolites.

Significance: This is novel regulatory mechanism controlling bacterial resistance to CAMPs and antibiotics.

Original languageEnglish (US)
Pages (from-to)32571-32582
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number47
DOIs
StatePublished - Nov 21 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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