Background: The CpxR/CpxA system facilitates E. coli resistance to antimicrobial peptides. However, many CpxR-dependent mechanisms remain elusive.
Results: The CpxR/CpxA system activates mar transcription, subsequently facilitating E. coli resistance to protamine via tripartite multidrug transporters.
Conclusion: A CpxR/CpxA-dependent regulatory cascade controls MarRA for CAMP resistance in response to aromatic metabolites.
Significance: This is novel regulatory mechanism controlling bacterial resistance to CAMPs and antibiotics.
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology