The consequences of not accounting for background selection in demographic inference

Gregory B. Ewing, Jeffrey Jensen

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Recently, there has been increased awareness of the role of background selection (BGS) in both data analysis and modelling advances. However, BGS is still difficult to take into account because of tractability issues with simulations and difficulty with nonequilibrium demographic models. Often, simple rescaling adjustments of effective population size are used. However, there has been neither a proper characterization of how BGS could bias or shift inference when not properly taken into account, nor a thorough analysis of whether rescaling is a sufficient solution. Here, we carry out extensive simulations with BGS to determine biases and behaviour of demographic inference using an approximate Bayesian approach. We find that results can be positively misleading with significant bias, and describe the parameter space in which BGS models replicate observed neutral nonequilibrium expectations.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalMolecular Ecology
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • evolutionary theory
  • natural selection and contemporary evolution
  • population dynamics
  • population genetics - theoretical

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

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