The concept of parasite-derived resistance-Deriving resistance genes from the parasite's own genome

J. C. Sanford, Stephen Johnston

Research output: Contribution to journalArticle

438 Citations (Scopus)

Abstract

A broadly-applicable strategy is proposed for genetically engineering resistance to parasites. The strategy involves deriving resistance genes from the genome of the parasite itself. Key gene products from the parasite, if present in a dysfunctional form, in excess, or at the wrong developmental stage, should disrupt the function of the parasite while having minimal affect on the host. Therefore, resistance might be routinely achieved by cloning the appropriate parasite gene, modifying its expression if necessary, and transforming it into the host genome. The QB bacteriophage is used to illustrate, specifically, how parasite-derived resistance might be engineered. Examples are given of pathogen-derived resistance as it already functions in nature, and potential applications of this strategy in agriculture are discussed. The advantages and limitations of parasite-derived resistance are outlined.

Original languageEnglish (US)
Pages (from-to)395-405
Number of pages11
JournalJournal of Theoretical Biology
Volume113
Issue number2
DOIs
StatePublished - Mar 21 1985
Externally publishedYes

Fingerprint

Parasites
Genome
Genes
Gene
parasites
genome
genes
Agriculture
Bacteriophages
Cloning
Pathogens
Excess
Resistance
Concepts
bacteriophages
Organism Cloning
molecular cloning
engineering
Engineering
developmental stages

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Applied Mathematics
  • Modeling and Simulation
  • Statistics and Probability
  • Medicine(all)

Cite this

The concept of parasite-derived resistance-Deriving resistance genes from the parasite's own genome. / Sanford, J. C.; Johnston, Stephen.

In: Journal of Theoretical Biology, Vol. 113, No. 2, 21.03.1985, p. 395-405.

Research output: Contribution to journalArticle

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