The complete genome sequence of shope (rabbit) fibroma virus

David O. Willer, Douglas McFadden, David H. Evans

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

We have determined the complete DNA sequence of the Leporipoxvirus Shope fibroma virus (SFV). The SFV genome spans 159.8 kb and encodes 165 putative genes of which 13 are duplicated in the 12.4-kb terminal inverted repeats. Although most SFV genes have homologs encoded by other Chordopoxvirinae, the SFV genome lacks a key gene required for the production of extracellular enveloped virus. SFV also encodes only the smaller ribonucleotide reductase subunit and has a limited nucleotide biosynthetic capacity. SFV preserves the Chordopoxvirinae gene order from S012L near the left end of the chromosome through to S142R (homologs of vaccinia F2L and B1R, respectively). The unique right end of SFV appears to be genetically unstable because when the sequence is compared with that of myxoma virus, five myxoma homologs have been deleted (C. Cameron, S. Hota-Mitchell, L. Chen, J. Barrett, J.-X. Cao, C. Macaulay, D. Willer, D. Evans, and G. McFadden, 1999, Virology 264, 298-318). Most other differences between these two Leporipoxviruses are located in the telomeres. Leporipoxviruses encode several genes not found in other poxviruses including four small hydrophobic proteins of unknown function (S023R, S119L, S125R, and S132L), an α 2,3-sialyltransferase (S143R), a protein belonging to the Ig-like protein superfamily (S141 R), and a protein resembling the DNA-binding domain of proteins belonging to the HIN-200 protein family S013L). SFV also encodes a type II DNA photolyase (S127L). Melanoplus sanguinipes entomopoxvirus encodes a similar protein, but SFV is the first mammalian virus potentially capable of photoreactivating ultraviolet DNA damage.

Original languageEnglish (US)
Pages (from-to)319-343
Number of pages25
JournalVirology
Volume264
Issue number2
DOIs
StatePublished - Nov 25 1999
Externally publishedYes

Fingerprint

Rabbit Fibroma Virus
Genome
Leporipoxvirus
Chordopoxvirinae
Proteins
Genes
Entomopoxvirinae
Myxoma virus
Deoxyribodipyrimidine Photo-Lyase
Sialyltransferases
Viruses
Poxviridae
Ribonucleotide Reductases
Vaccinia
Virology
Myxoma
Gene Order
Terminal Repeat Sequences
Telomere
DNA-Binding Proteins

ASJC Scopus subject areas

  • Virology

Cite this

The complete genome sequence of shope (rabbit) fibroma virus. / Willer, David O.; McFadden, Douglas; Evans, David H.

In: Virology, Vol. 264, No. 2, 25.11.1999, p. 319-343.

Research output: Contribution to journalArticle

Willer, David O. ; McFadden, Douglas ; Evans, David H. / The complete genome sequence of shope (rabbit) fibroma virus. In: Virology. 1999 ; Vol. 264, No. 2. pp. 319-343.
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