The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20

George Pettit; Jun-Ping Xu; Jean Chapuis; Noeleen Melody

doi:10.1021/acs.jnatprod.5b00129

The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20

George Pettit, Jun-Ping Xu, Jean Chapuis, Noeleen Melody

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

For the purpose of advancing knowledge of the structural variations available in the natural cephalostatins contained in the marine worm Cephalodiscus gilchristi, the isolation and structure of the 20th member (1) has been accomplished (10^-7 % yield). In turn cephalostatin 20 (1) proved to be enough for an initial SAR study comprising six important human cancer cell lines. A parallel objective was aimed at the possible discovery of a natural cephalostatin with a more accessible structure for total synthesis and/or synthetic modifications, but with powerful cancer cell growth inhibition.

Original language	English (US)
Pages (from-to)	1446-1450
Number of pages	5
Journal	Journal of Natural Products
Volume	78
Issue number	6
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00129
State	Published - Jun 26 2015

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.5b00129

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The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20

Abstract

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