The CEPH consortium linkage map of human chromosome 1

Nicholas C. Dracopoli, Peter O'Connell, Tami I. Elsner, Jean Marc Lalouel, Raymond L. White, Kenneth H. Buetow, Darryl Y. Nishimura, Jeffrey C. Murray, Cynthia Helms, Santosh K. Mishra, Helen Donis-Keller, Jeffrey M. Hall, Ming K. Lee, Mary Claire King, John Attwood, Newton E. Morton, Elizabeth B. Robson, Melanie Mahtani, Huntington F. Willard, Nicola J. RoyleIla Patel, Alec J. Jeffreys, Vera Verga, Trefor Jenkins, James L. Weber, Anna L. Mitchell, Allen E. Bale

Research output: Contribution to journalArticle

112 Scopus citations

Abstract

This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of human chromosome 1. The map contains 101 loci defined by genotypes generated from CEPH family DNAs with 146 different contributions from 11 laboratories. A total of 58 loci are uniquely placed on the map with likelihood support of at least 1000:1. The map extends from loci in the terminal bands of both chromosome arms (locus D1Z2 in 1p36.3 and D1S68 in 1q44) and is anchored at the centromere by the D1Z5 α-satellite polymorphism. With the exception of a single locus, the remaining loci are arrayed on the fixed map in short intervals and their possible locations are indicated. Multipoint linkage analyses provided estimates that the male, female, and sex-averaged maps extend for 308, 478, and 390 cM, respectively. The sex-averaged map contains only four intervals > 15 cM, and the mean genetic distance between the 58 uniquely placed loci is 6.7 cM.

Original languageEnglish (US)
Pages (from-to)686-700
Number of pages15
JournalGenomics
Volume9
Issue number4
DOIs
StatePublished - Apr 1991
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Dracopoli, N. C., O'Connell, P., Elsner, T. I., Lalouel, J. M., White, R. L., Buetow, K. H., Nishimura, D. Y., Murray, J. C., Helms, C., Mishra, S. K., Donis-Keller, H., Hall, J. M., Lee, M. K., King, M. C., Attwood, J., Morton, N. E., Robson, E. B., Mahtani, M., Willard, H. F., ... Bale, A. E. (1991). The CEPH consortium linkage map of human chromosome 1. Genomics, 9(4), 686-700. https://doi.org/10.1016/0888-7543(91)90362-I