@article{adb20df2298643cbac61d3f849fe57de,
title = "The CEPH consortium linkage map of human chromosome 1",
abstract = "This paper describes the Centre d'Etude du Polymorphisme Humain (CEPH) consortium linkage map of human chromosome 1. The map contains 101 loci defined by genotypes generated from CEPH family DNAs with 146 different contributions from 11 laboratories. A total of 58 loci are uniquely placed on the map with likelihood support of at least 1000:1. The map extends from loci in the terminal bands of both chromosome arms (locus D1Z2 in 1p36.3 and D1S68 in 1q44) and is anchored at the centromere by the D1Z5 α-satellite polymorphism. With the exception of a single locus, the remaining loci are arrayed on the fixed map in short intervals and their possible locations are indicated. Multipoint linkage analyses provided estimates that the male, female, and sex-averaged maps extend for 308, 478, and 390 cM, respectively. The sex-averaged map contains only four intervals > 15 cM, and the mean genetic distance between the 58 uniquely placed loci is 6.7 cM.",
author = "Dracopoli, {Nicholas C.} and Peter O'Connell and Elsner, {Tami I.} and Lalouel, {Jean Marc} and White, {Raymond L.} and Buetow, {Kenneth H.} and Nishimura, {Darryl Y.} and Murray, {Jeffrey C.} and Cynthia Helms and Mishra, {Santosh K.} and Helen Donis-Keller and Hall, {Jeffrey M.} and Lee, {Ming K.} and King, {Mary Claire} and John Attwood and Morton, {Newton E.} and Robson, {Elizabeth B.} and Melanie Mahtani and Willard, {Huntington F.} and Royle, {Nicola J.} and Ila Patel and Jeffreys, {Alec J.} and Vera Verga and Trefor Jenkins and Weber, {James L.} and Mitchell, {Anna L.} and Bale, {Allen E.}",
note = "Funding Information: We thank Professor Jean Dausset and the stalf of the CEPH, especially Dr. Howard Cann, for their invaluable help in providing DNA samples. data, and other forms of support. Obviously. this map could not have been developed without their commitment to the completion of the human genetic linkage map. We also thank the NIH Center for Human Genome Research (NCHGR) for providing financial support and facilities for the CEPH chromosome 1 consortium meeting. Arrangements for this meeting were made by Dr. Mark Guyer, who has provided continuous encouragement and support for this project.. N.C.D. gratefully acknowledges David Housman{\textquoteright}s advice and support for all the work carried out at MIT, and also thanks to Mark Daly and Steve Lincoln for help with the new version of MAPMAKER. The following grant support from the National Institutes Health is acknowledged: CA44176 (to N.C.D., Biology Department, MIT), DE08559 and GM40864 (to .J.C.M., Department of Pediatrics, University of Iowa Medical School), HG00304 (to H.D-K, Department of Genetics, Washington IJniversity Medical School), GM40886 (to R.L.W.. Howard Hughes Medical Institute, University of Utah), CA27632 with a supplement from the NCHGR (to M.C.K., School Public Health. UC Rerkeleyl, HG0024R (to J.L.W., Marshfield Medical Research Foundation), HG00107 to (H.F.W., Department of Genetics, Stanford University). (Grant support from the following institutions is also gratefully acknowledged: Howard Hughes Medical Institute (to R.L.W., Funding Information: Howard Hughes Medical Institute, University of Utah), Medical Research Council of Great Britain (MRC) as part of the UK Human Genome Project to E.B.R., J.A., Galton Laboratory, University College, London, and A.d.J., Department of Genetics, University of Leicester), the Cancer Research Campaign of Great Britain (to N.M., Department of Community Medicine, University of Southampton), Wolfson Foundation Grants and the Lister Institute Research Fellowship (to A.J.J., Department of Genetics, University of Leicester).",
year = "1991",
month = apr,
doi = "10.1016/0888-7543(91)90362-I",
language = "English (US)",
volume = "9",
pages = "686--700",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "4",
}