The cell biology of the endocytic system from an evolutionary perspective

Jeremy G. Wideman, Ka Fai Leung, Mark C. Field, Joel B. Dacks

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Evolutionary cell biology can afford an interdisciplinary comparative view that gives insights into both the functioning of modern cells and the origins of cellular systems, including the endocytic organelles. Here, we explore several recent evolutionary cell biology studies, highlighting investigations into the origin and diversity of endocytic systems in eukaryotes. Beginning with a brief overview of the eukaryote tree oflife, we show how understanding the endocytic machinery in a select, but diverse, array of organisms provides insights into endo-cytic system origins and predicts the likely configuration in the last eukaryotic common ancestor (LECA). Next, we consider three examples in which a comparative approach yielded insight into the function of modern cellular systems. First, using ESCRT-0 as an example, we show how comparative cell biology can discover both lineage-specific novelties (ESCRT-0) as well as previously ignored ancient proteins (Tom1), likely of both evolutionary and functional importance. Second, we highlight the power of comparative cell biology for discovery of previously ignored but potentially ancient complexes (AP5). Finally, using examples from ciliates and trypanosomes, we show that not all organisms possess canonical endocytic pathways, but instead likely evolved lineage-specific mechanisms. Drawing from these case studies, we conclude that a comparative approach is a powerful strategy for advancing knowledge about the general mechanisms and functions of endocytic systems.

Original languageEnglish (US)
Article numbera016998
JournalCold Spring Harbor perspectives in biology
Volume6
Issue number4
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'The cell biology of the endocytic system from an evolutionary perspective'. Together they form a unique fingerprint.

Cite this