The case for plant-made veterinary immunotherapeutics

Edward Topp, Rebecca Irwin, Tim McAllister, Martin Lessard, Jussi J. Joensuu, Igor Kolotilin, Udo Conrad, Eva Stöger, Tsafrir Leket-Mor, Heribert Warzecha, J. Chris Hall, Michael D. McLean, Eric Cox, Bert Devriendt, Andrew Potter, Ann Depicker, Vikram Virdi, Larry Holbrook, Ketan Doshi, Marike DussaultRobert Friendship, Oksana Yarosh, Han Sang Yoo, Jacqueline MacDonald, Rima Menassa

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The excessive use of antibiotics in food animal production has contributed to resistance in pathogenic bacteria, thereby triggering regulations and consumer demands to limit their use. Alternatives for disease control are therefore required that are cost-effective and compatible with intensive production. While vaccines are widely used and effective, they are available against a minority of animal diseases, and development of novel vaccines and other immunotherapeutics is therefore needed. Production of such proteins recombinantly in plants can provide products that are effective and safe, can be orally administered with minimal processing, and are easily scalable with a relatively low capital investment. The present report thus advocates the use of plants for producing vaccines and antibodies to protect farm animals from diseases that have thus far been managed with antibiotics; and highlights recent advances in product efficacy, competitiveness, and regulatory approval.

Original languageEnglish (US)
JournalBiotechnology Advances
DOIs
StateAccepted/In press - Sep 29 2015

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Keywords

  • Antibiotic resistance
  • Antibody
  • Immunotherapeutic
  • Livestock production
  • Molecular farming
  • Plant biotechnology
  • Recombinant protein
  • Veterinary vaccine

ASJC Scopus subject areas

  • Biotechnology

Cite this

Topp, E., Irwin, R., McAllister, T., Lessard, M., Joensuu, J. J., Kolotilin, I., Conrad, U., Stöger, E., Leket-Mor, T., Warzecha, H., Hall, J. C., McLean, M. D., Cox, E., Devriendt, B., Potter, A., Depicker, A., Virdi, V., Holbrook, L., Doshi, K., ... Menassa, R. (Accepted/In press). The case for plant-made veterinary immunotherapeutics. Biotechnology Advances. https://doi.org/10.1016/j.biotechadv.2016.02.007