The broad spectrum of quality in deceased donor kidneys

Jesse Dylan Schold, Bruce Kaplan, Rajendra S. Baliga, Herwig Ulf Meier-Kriesche

    Research output: Contribution to journalArticlepeer-review

    146 Scopus citations

    Abstract

    The quality of the deceased donor organ clearly is one of the most crucial factors in determining graft survival and function in recipients of a kidney transplant. There has been considerable effort made towards evaluating these organs culminating in an amendment to allocation policy with the introduction of the expanded criteria donor (ECD) policy. Our study, from first solitary adult deceased donor transplant recipients from 1996 to 2002 in the National Scientific Transplant Registry database, presents a donor kidney risk grade based on significant donor characteristics, donor-recipient matches and cold ischemia time, generated directly from their risk for graft loss. We investigated the impact of our donor risk grade in a naïve cohort on short- and long-term graft survival, as well as in subgroups of the population. The projected half-lives for overall graft survival in recipients by donor risk grade were I (10.7 years), II (10.0 years). III (7.9 years), IV (5.7 years) and V (4.5 years). This study indicates that there is great variability in the quality of deceased donor kidneys and that the assessment of risk might be enhanced by this scoring system as compared to the simple two-tiered system of the current ECD classification.

    Original languageEnglish (US)
    Pages (from-to)757-765
    Number of pages9
    JournalAmerican Journal of Transplantation
    Volume5
    Issue number4 I
    DOIs
    StatePublished - Apr 2005

    Keywords

    • Deceased donor
    • Expanded criteria donor
    • Graft survival
    • Kidney
    • Renal transplantation
    • Risk factors

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Transplantation
    • Pharmacology (medical)

    Fingerprint Dive into the research topics of 'The broad spectrum of quality in deceased donor kidneys'. Together they form a unique fingerprint.

    Cite this