The Bacterial Microbiome and Virome Milestones of Infant Development

Efrem Lim, David Wang, Lori R. Holtz

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

The human gut harbors a complex community of bacteria, viruses, fungi, protists, and other microorganisms (collectively termed the microbiome) that impact health and disease. Emerging studies indicate that the gut bacterial microbiome and virome play an important role in healthy infant development. In turn, the composition of the microbiome during development can be influenced by factors such as dietary, environmental, and maternal conditions. As such, the microbiome trajectory during early infancy could be predictors of healthy development. Conversely, adverse early events in life may have consequences later in life. This review focuses on our understanding of the bacterial microbiome and virome during early development, conditions that might influence these processes, and their long-term implications for infant health.

Original languageEnglish (US)
Pages (from-to)801-810
Number of pages10
JournalTrends in Microbiology
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

Fingerprint

Microbiota
Child Development
Fungi
Mothers
Viruses
Bacteria
Health

Keywords

  • infant
  • microbiome
  • virome

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Virology

Cite this

The Bacterial Microbiome and Virome Milestones of Infant Development. / Lim, Efrem; Wang, David; Holtz, Lori R.

In: Trends in Microbiology, Vol. 24, No. 10, 01.10.2016, p. 801-810.

Research output: Contribution to journalReview article

Lim, Efrem ; Wang, David ; Holtz, Lori R. / The Bacterial Microbiome and Virome Milestones of Infant Development. In: Trends in Microbiology. 2016 ; Vol. 24, No. 10. pp. 801-810.
@article{6f8b9f6562e54b57939d6693cdd3a54e,
title = "The Bacterial Microbiome and Virome Milestones of Infant Development",
abstract = "The human gut harbors a complex community of bacteria, viruses, fungi, protists, and other microorganisms (collectively termed the microbiome) that impact health and disease. Emerging studies indicate that the gut bacterial microbiome and virome play an important role in healthy infant development. In turn, the composition of the microbiome during development can be influenced by factors such as dietary, environmental, and maternal conditions. As such, the microbiome trajectory during early infancy could be predictors of healthy development. Conversely, adverse early events in life may have consequences later in life. This review focuses on our understanding of the bacterial microbiome and virome during early development, conditions that might influence these processes, and their long-term implications for infant health.",
keywords = "infant, microbiome, virome",
author = "Efrem Lim and David Wang and Holtz, {Lori R.}",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.tim.2016.06.001",
language = "English (US)",
volume = "24",
pages = "801--810",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - The Bacterial Microbiome and Virome Milestones of Infant Development

AU - Lim, Efrem

AU - Wang, David

AU - Holtz, Lori R.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The human gut harbors a complex community of bacteria, viruses, fungi, protists, and other microorganisms (collectively termed the microbiome) that impact health and disease. Emerging studies indicate that the gut bacterial microbiome and virome play an important role in healthy infant development. In turn, the composition of the microbiome during development can be influenced by factors such as dietary, environmental, and maternal conditions. As such, the microbiome trajectory during early infancy could be predictors of healthy development. Conversely, adverse early events in life may have consequences later in life. This review focuses on our understanding of the bacterial microbiome and virome during early development, conditions that might influence these processes, and their long-term implications for infant health.

AB - The human gut harbors a complex community of bacteria, viruses, fungi, protists, and other microorganisms (collectively termed the microbiome) that impact health and disease. Emerging studies indicate that the gut bacterial microbiome and virome play an important role in healthy infant development. In turn, the composition of the microbiome during development can be influenced by factors such as dietary, environmental, and maternal conditions. As such, the microbiome trajectory during early infancy could be predictors of healthy development. Conversely, adverse early events in life may have consequences later in life. This review focuses on our understanding of the bacterial microbiome and virome during early development, conditions that might influence these processes, and their long-term implications for infant health.

KW - infant

KW - microbiome

KW - virome

UR - http://www.scopus.com/inward/record.url?scp=84977660014&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84977660014&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2016.06.001

DO - 10.1016/j.tim.2016.06.001

M3 - Review article

VL - 24

SP - 801

EP - 810

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 10

ER -