@article{5289c7f31f774b2a8743408eb446b2f1,
title = "The Associations Between Polygenic Risk, Sensation Seeking, Social Support, and Alcohol Use in Adulthood",
abstract = "Genetic predispositions play an important role in alcohol use. Understanding the psychosocial mechanisms through which genetic risk unfolds to influence alcohol use outcomes is critical for identifying modifiable targets and developing prevention and intervention efforts. In this study, we examined the role of sensation seeking and social support from family and friends in linking genetic risk to alcohol use. We also examined the role of social support in moderating the associations between genetic risk and sensation seeking and alcohol use. Data were drawn from a sample of 2,836 European American adults from the Collaborative Study on the Genetics of Alcoholism (46% male, mean age = 35.65, standard deviation [SD] = 10.78). Results from path analysis indicated that genome-wide polygenic scores for alcohol consumption (alc-GPS) were associated with higher sensation seeking, which in turn was associated with higher levels of alcohol use. alc-GPS was also associated with higher alcohol use indirectly via lower levels of family support. In addition, high friend support attenuated the association between alc-GPS and sensation seeking and alcohol use. The pattern of associations was similar for males and females, with some differences in the associations between social support and alcohol use observed across age. Our findings highlight the important role of intermediate phenotypes and gene–environment interplay in the pathways of risk from genetic predispositions to complex alcohol use outcomes.",
keywords = "Alcohol use, Gene–environment interplay, Polygenic scores, Sensation seeking, Social support",
author = "Jinni Su and Kuo, {Sally I.Chun} and Fazil Aliev and Grace Chan and Edenberg, {Howard J.} and Chella Kamarajan and McCutcheon, {Vivia V.} and Meyers, {Jacquelyn L.} and Marc Schuckit and Jay Tischfield and Dick, {Danielle M.}",
note = "Funding Information: The authors acknowledge the Collaborative Study on the Genetics of Alcoholism (COGA), Principal Investigators (PIs) B. Porjesz, V. Hesselbrock, T. Foroud; Scientific Director A. Agrawal; Translational Director Danielle M. Dick, which includes 11 different centers: University of Connecticut (V. Hesselbrock); Indiana University (Howard J. Edenberg, T. Foroud, J. Nurnberger Jr., Y. Liu); University of Iowa (S. Kuperman, J. Kramer); SUNY Downstate (B. Porjesz, Jacquelyn L. Meyers, Chella Kamarajan, A. Pandey); Washington University in St. Louis (L. Bierut, J. Rice, K. Bucholz, A. Agrawal); University of California at San Diego (Marc Schuckit); Rutgers University (Jay Tischfield, A. Brooks, R. Hart); the Children{\textquoteright}s Hospital of Philadelphia, the University of Pennsylvania (L. Almasy); Virginia Commonwealth University (Danielle M. Dick, J. Salvatore); Icahn School of Medicine at Mount Sinai (A. Goate, M. Kapoor, P. Slesinger); and Howard University (D. Scott). Other COGA collaborators include L. Bauer (University of Connecticut); L. Wetherill, X. Xuei, D. Lai, S. O{\textquoteright}Connor, M. Plawecki, S. Lourens (Indiana University); L. Acion (University of Iowa); Grace Chan (University of Iowa; University of Connecticut); D. B. Chorlian, J. Zhang, S. Kinreich, G. Pandey (State University of New York Downstate); M. Chao (Icahn School of Medicine at Mount Sinai); A. Anokhin, Vivia V. McCutcheon, S. Saccone (Washington University); Fazil Aliev, P. Barr (Virginia Commonwealth University); H. Chin and A. Parsian are the National Institute on Alcohol Abuse and Alcoholism (NIAAA) staff collaborators. We continue to be inspired by our memories of Henri Begleiter and Theodore Reich, founding PI and co-PI of COGA, and also owe a debt of gratitude to other past organizers of COGA, including Ting-Kai Li, P. Michael Conneally, Raymond Crowe, and Wendy Reich, for their critical contributions. This national collaborative study was supported by National Institutes of Health (NIH) Grant U10AA008401 from the NIAAA and the National Institute on Drug Abuse. Publisher Copyright: {\textcopyright} 2021 American Psychological Association",
year = "2021",
doi = "10.1037/abn0000568",
language = "English (US)",
volume = "130",
pages = "525--536",
journal = "Journal of Abnormal Psychology",
issn = "0021-843X",
publisher = "American Psychological Association Inc.",
number = "5",
}