TY - JOUR
T1 - The associations between physical activity, inflammation, and coagulation markers, in people with metabolic syndrome
T2 - The ATTICA study
AU - Pitsavos, Christos
AU - Panagiotakos, Demosthenes B.
AU - Chrysohoou, Christina
AU - Kavouras, Stavros
AU - Stefanadis, Christodoulos
N1 - Funding Information:
The ATTICA study is funded by research grants from the Hellenic Society of Cardiology. The authors would like to thank the field investigators of the ‘ATTICA’ study: Dr John Skoumas (principal field investigator), Dr Natasa Katinioti (physical examination), Dr Spiros Vellas (physical examination), Dr Efi Tsetsekou (physical/psychological evaluation), Dr Dina Masoura (physical examination), Dr Lambros Papadimitriou (physical examination), as well as the technical team: Dr Marina Toutouza (biochemical analysis), Ms Carmen Vasiliadou (genetic analysis), Mr Manolis Kambaxis (nutritional evaluation), Ms Konstadina Paliou (nutritional evaluation), Ms Chrysoula Tselika (biochemical evaluation), Ms Sia Poulopoulou (biochemical evaluation) and Ms Maria Toutouza (database management).
PY - 2005/4
Y1 - 2005/4
N2 - Objective Metabolic syndrome is a condition that promotes atherosclerosis and increases the risk of cardiovascular mortality and morbidity. We evaluated whether leisure time physical activity is associated with the levels of inflammatory and coagulation markers, in people with metabolic syndrome. Methods From May 2001 to December 2002 we randomly enrolled 1514 men and 1528 women (>18 years old), without any clinical evidence of cardiovascular disease, stratified by age-gender (census 2001). The population of the study was divided into those who fulfilled the NCEP ATP III criteria for the metabolic syndrome (n = 701 or 33% men and 13% women) and the rest of the participants (n = 2341). We assessed the relationship between self-reported physical activity status and inflammatory, and coagulation markers [i.e., C-reactive protein (CRP), serum amyloid-A (SAA), interleukin (IL)-6, tumour necrosis factor (TNF)-α, white blood cell (WBC) counts, and fibrinogen (FIB)], after taking into account the effect of several confounders. Results Of the non-metabolic syndrome group, 56% of men and 58% of women were classified as sedentary, while of the metabolic syndrome group 58% men and 72% women were sedentary. After controlling for various potential confounders we found that physically active individuals with the metabolic syndrome had 36% lower levels of CRP, 15% lower levels of WBC, 19% lower levels of SAA, 15% lower levels of TNF-α, 30% lower levels of IL-6 and 15% lower levels of FIB, compared to sedentary (all P<0.05). Similar results were observed in the non-metabolic syndrome group. Conclusions The adoption of a physically active lifestyle is independently associated with lower levels of the investigated biomarkers in individuals with the metabolic syndrome. The latter may suggest a pathway for reducing cardiovascular events, even in high-risk people.
AB - Objective Metabolic syndrome is a condition that promotes atherosclerosis and increases the risk of cardiovascular mortality and morbidity. We evaluated whether leisure time physical activity is associated with the levels of inflammatory and coagulation markers, in people with metabolic syndrome. Methods From May 2001 to December 2002 we randomly enrolled 1514 men and 1528 women (>18 years old), without any clinical evidence of cardiovascular disease, stratified by age-gender (census 2001). The population of the study was divided into those who fulfilled the NCEP ATP III criteria for the metabolic syndrome (n = 701 or 33% men and 13% women) and the rest of the participants (n = 2341). We assessed the relationship between self-reported physical activity status and inflammatory, and coagulation markers [i.e., C-reactive protein (CRP), serum amyloid-A (SAA), interleukin (IL)-6, tumour necrosis factor (TNF)-α, white blood cell (WBC) counts, and fibrinogen (FIB)], after taking into account the effect of several confounders. Results Of the non-metabolic syndrome group, 56% of men and 58% of women were classified as sedentary, while of the metabolic syndrome group 58% men and 72% women were sedentary. After controlling for various potential confounders we found that physically active individuals with the metabolic syndrome had 36% lower levels of CRP, 15% lower levels of WBC, 19% lower levels of SAA, 15% lower levels of TNF-α, 30% lower levels of IL-6 and 15% lower levels of FIB, compared to sedentary (all P<0.05). Similar results were observed in the non-metabolic syndrome group. Conclusions The adoption of a physically active lifestyle is independently associated with lower levels of the investigated biomarkers in individuals with the metabolic syndrome. The latter may suggest a pathway for reducing cardiovascular events, even in high-risk people.
KW - atherosclerosis
KW - inflammation
KW - metabolic syndrome
KW - physical activity
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UR - http://www.scopus.com/inward/citedby.url?scp=17744397136&partnerID=8YFLogxK
U2 - 10.1097/01.hjr.0000164690.50200.43
DO - 10.1097/01.hjr.0000164690.50200.43
M3 - Article
C2 - 15785301
AN - SCOPUS:17744397136
SN - 2047-4873
VL - 12
SP - 151
EP - 158
JO - European Journal of Preventive Cardiology
JF - European Journal of Preventive Cardiology
IS - 2
ER -