The Antineoplastic Quassinoids Of Simaba Cuspidata Spruce And Ailanthus Grand Is Prain

Judith Polonsky, Zoia Vakon, Charles MoKetti, George Pettit, Cherry L. Herald, John A. Rideout, Shri B. Saha, Hari N. Khastgir

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The South American Simaba cuspidata Spruce and North Indian Ailanthus granáis Prain were investigated as sources of potentially useful antineoplastic agents. Both of these Simaroubaceae plant species were found to produce 6a-tigloyloxychaparrinone (4a) and the new quassinoid 6a-tigloyloxychaparrin (3b). The latter structure was determined by interpretation of spectral data and oxidation to 6a-tigloyloxychaparrinone (4a). While both glycol 3b and -ketol 4a were found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell line, only the -ketol (4a) inhibited growth of the corresponding in vivo system.

Original languageEnglish (US)
Pages (from-to)503-509
Number of pages7
JournalJournal of Natural Products
Volume43
Issue number4
DOIs
StatePublished - Jul 1980

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Polonsky, J., Vakon, Z., MoKetti, C., Pettit, G., Herald, C. L., Rideout, J. A., Saha, S. B., & Khastgir, H. N. (1980). The Antineoplastic Quassinoids Of Simaba Cuspidata Spruce And Ailanthus Grand Is Prain. Journal of Natural Products, 43(4), 503-509. https://doi.org/10.1021/np50010a012