The antineoplastic quassinoids of Simaba Cuspid at a spruce and Ailanthus Grandis prain

Judith Polonsky, Zoia Vakon, Charles MoKetti, George Pettit, Cherry L. Herald, John A. Rideout, Shri B. Saha, Hari N. Khastgir

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The South American Simaba cuspidata Spruce and North Indian Ailanthus grandis Prain were investigated as sources of potentially useful antineoplastic agents. Both of these Simaroubaceae plant species were found to produce 6α-tigloyloxychaparrinone (4a) and the new quassinoid 6α-tigloyloxychaparrin (3b). The latter structure was determined by interpretation of spectral data and oxidation to 6α-tigloyloxychaparrinone (4a). While both glycol 3b and α-ketol 4a were found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell line, only the α-ketol (4a) inhibited growth of the corresponding in vivo system.

Original languageEnglish (US)
Pages (from-to)503-509
Number of pages7
JournalJournal of Natural Products (Lloydia)
Volume43
Issue number4
StatePublished - 1980

Fingerprint

Ailanthus
Simaroubaceae
Quassins
Cuspid
lymphocytic leukemia
glycols
antineoplastic agents
Antineoplastic Agents
spectral analysis
Picea
cell lines
oxidation
Lymphoid Leukemia
Glycols
mice
Growth
Cells
Cell Line
Oxidation

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Polonsky, J., Vakon, Z., MoKetti, C., Pettit, G., Herald, C. L., Rideout, J. A., ... Khastgir, H. N. (1980). The antineoplastic quassinoids of Simaba Cuspid at a spruce and Ailanthus Grandis prain. Journal of Natural Products (Lloydia), 43(4), 503-509.

The antineoplastic quassinoids of Simaba Cuspid at a spruce and Ailanthus Grandis prain. / Polonsky, Judith; Vakon, Zoia; MoKetti, Charles; Pettit, George; Herald, Cherry L.; Rideout, John A.; Saha, Shri B.; Khastgir, Hari N.

In: Journal of Natural Products (Lloydia), Vol. 43, No. 4, 1980, p. 503-509.

Research output: Contribution to journalArticle

Polonsky, J, Vakon, Z, MoKetti, C, Pettit, G, Herald, CL, Rideout, JA, Saha, SB & Khastgir, HN 1980, 'The antineoplastic quassinoids of Simaba Cuspid at a spruce and Ailanthus Grandis prain', Journal of Natural Products (Lloydia), vol. 43, no. 4, pp. 503-509.
Polonsky, Judith ; Vakon, Zoia ; MoKetti, Charles ; Pettit, George ; Herald, Cherry L. ; Rideout, John A. ; Saha, Shri B. ; Khastgir, Hari N. / The antineoplastic quassinoids of Simaba Cuspid at a spruce and Ailanthus Grandis prain. In: Journal of Natural Products (Lloydia). 1980 ; Vol. 43, No. 4. pp. 503-509.
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