The Antineoplastic Quassinoids Of Simaba Cuspidata Spruce And Ailanthus Grand Is Prain

Judith Polonsky; Zoia Vakon; Charles MoKetti; George Pettit; Cherry L. Herald; John A. Rideout; Shri B. Saha; Hari N. Khastgir

doi:10.1021/np50010a012

The Antineoplastic Quassinoids Of Simaba Cuspidata Spruce And Ailanthus Grand Is Prain

Judith Polonsky, Zoia Vakon, Charles MoKetti, George Pettit, Cherry L. Herald, John A. Rideout, Shri B. Saha, Hari N. Khastgir

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23 Scopus citations

Abstract

The South American Simaba cuspidata Spruce and North Indian Ailanthus granáis Prain were investigated as sources of potentially useful antineoplastic agents. Both of these Simaroubaceae plant species were found to produce 6a-tigloyloxychaparrinone (4a) and the new quassinoid 6a-tigloyloxychaparrin (3b). The latter structure was determined by interpretation of spectral data and oxidation to 6a-tigloyloxychaparrinone (4a). While both glycol 3b and -ketol 4a were found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell line, only the -ketol (4a) inhibited growth of the corresponding in vivo system.

Original language	English (US)
Pages (from-to)	503-509
Number of pages	7
Journal	Journal of Natural Products
Volume	43
Issue number	4
DOIs	https://doi.org/10.1021/np50010a012
State	Published - Jul 1980

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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abstract = "The South American Simaba cuspidata Spruce and North Indian Ailanthus gran{\'a}is Prain were investigated as sources of potentially useful antineoplastic agents. Both of these Simaroubaceae plant species were found to produce 6a-tigloyloxychaparrinone (4a) and the new quassinoid 6a-tigloyloxychaparrin (3b). The latter structure was determined by interpretation of spectral data and oxidation to 6a-tigloyloxychaparrinone (4a). While both glycol 3b and -ketol 4a were found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell line, only the -ketol (4a) inhibited growth of the corresponding in vivo system.",

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AU - Polonsky, Judith

AU - Vakon, Zoia

AU - MoKetti, Charles

AU - Pettit, George

AU - Herald, Cherry L.

AU - Rideout, John A.

AU - Saha, Shri B.

AU - Khastgir, Hari N.

PY - 1980/7

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AB - The South American Simaba cuspidata Spruce and North Indian Ailanthus granáis Prain were investigated as sources of potentially useful antineoplastic agents. Both of these Simaroubaceae plant species were found to produce 6a-tigloyloxychaparrinone (4a) and the new quassinoid 6a-tigloyloxychaparrin (3b). The latter structure was determined by interpretation of spectral data and oxidation to 6a-tigloyloxychaparrinone (4a). While both glycol 3b and -ketol 4a were found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell line, only the -ketol (4a) inhibited growth of the corresponding in vivo system.

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The Antineoplastic Quassinoids Of Simaba Cuspidata Spruce And Ailanthus Grand Is Prain

Abstract

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